PAR-13-364 Development of Assays for High-Throughput Screening for Use in Probe and Pre-therapeutic Discovery (R01)
The participating NIH Institutes and Centers invite Research Project Grant (R01) applications to develop assays for high throughput screening (HTS) for use in Probe and Pre-therapeutic Discovery. Through this FOA, NIH wishes to stimulate research in developing assays for specific biological targets and disease mechanisms relevant to the mission of participating NIH Institutes with the intent to screen for small molecule compounds that show potential as probes for use in advancing knowledge about the known targets, identifying new targets, or as pre-therapeutic leads; and establishing collaboration with screening centers that have the requisite expertise and experience needed in implementation of HTS assays for the discovery and development of small molecule chemical probes.
- Hold an M.D. or foreign equivalent, or a D.O. degree from an accredited institution.
- Have a valid, active U.S. medical license at the time of application, but do not have to be U.S. citizens.
- Be working at a U.S. degree-granting institution that would be able to receive an award as an organization with 501(c)(3) Internal Revenue Service status.
- Have a full-time faculty appointment as assistant professor. Have been appointed to their first assistant professor position between November 1, 2008 and November 1, 2012.
- Have his/her own research space.
- Propose a clinical research project, as defined by the Doris Duke Charitable Foundation, in any disease area. See definition in the Request for Applications.
- Not be the principal investigator of a multi-year grant with annual direct funding in the amount of $225,000 or higher with start date prior to and inclusive of July 1, 2014.
- Not be the principal investigator or co-principal investigator on a National Institutes of Health R01 research grant or equivalent that has a start date prior to and inclusive of July 1, 2014.
- Be guaranteed a minimum overall research time protection of 75% of full-time professional effort by the institution where the applicant has an appointment. There is no explicit minimum percent effort that must be dedicated to the CSDA project.
This FOA seeks to establish a stream of scientifically and technologically outstanding assays for screening by the NIH Molecular Libraries Production Centers Network (MLPCN) in the Molecular Libraries Program (MLP) and other academic centers. One important criterion for this initiative is novelty, so applicants are therefore encouraged to avoid focusing on areas and approaches that have been extensively targeted in other settings. Assays should be relevant to the scope of research in at least one of the participating NIH Institutes.
Application Due Date: Standard dates apply
Expiration Date: January 8, 2017