Researchers Receive Funding for Program on Sudden Cardiac Arrest
Madison - A multidisciplinary team of University of Wisconsin-Madison physiologists and cardiac specialists have launched a new program to study the mysteries of sudden cardiac arrest, thanks to a grant from the National Heart, Blood and Lung Institute.
The grant, which will pay $9.77 million over five years, will establish a program to study sudden cardiac arrest due to calcium-triggered arrhythmias. Researchers will study the genetics and electrophysiological mechanisms of inherited diseases and syndromes such as catecholaminergic polymorphic ventricular tachycardia (CPVT), long QT syndrome, and hypertrophic cardiomyopathy.
In each instance, sudden cardiac arrest is associated with a surge in catecholamines (of which adrenaline is one) in response to stressors such as exercise.
"This grant demonstrates our strength in translational research, in bringing science from the bench to the bedside," said principal investigator Dr. Richard Moss, professor of physiology and senior associate dean for basic research, biotechnology and graduate studies at the UW School of Medicine and Public Health.
Moss said the grant is a multi-investigator program project that builds upon historic excellence at UW-Madison, which has long been a leader in studying and treating patients with inherited arrhythmias and has strong basic research in the area, including invaluable research core facilities that develop and characterize animal models of cardiac disease.
Besides Moss, lead investigators for the program project include Drs. Lee Eckhardt, assistant professor of cardiovascular medicine; Jonathan Makielski, professor of cardiovascular medicine; and Hector Valdivia, professor of physiology, all of the UW School of Medicine and Public Health. Dr. Michael Ackerman, professor of pediatrics at the Mayo Clinic Medical School, is also an investigator.
Directors of the Scientific Core Facilities include Dr. Patricia Powers, scientist in the department of physiology and UW Biotechnology Center; and Dr. Timothy Hacker, associate scientist, division of cardiovascular medicine.
Date Published: 02/05/2010