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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: FISH- 1q21 gain, CKS1B gene

Test Code(s): 870F55 / HC870F55

CPT Code(s): 88271x2, 88275

Methodology: Fluorescence In Situ Hybridization (FISH)

Clinical Significance: Detection of gain of 1q associated with multiple myeloma and other plasma cell disorders.  Aids in diagnosis of hematologic disorders and for monitoring disease after treatment or bone marrow transplant.

Testing Site: Testing will be sent to an approved reference laboratory.

Days Performed: Mon-Sat.

Turnaround Time: Routine: 3 - 5 days.


Specimen Requirements

Specimen: Blood or bone marrow

Collection Instructions: Blood or bone marrow must be received and processed by WSLH within 24 hours of collection. Specimen must be received in UWHC Core Laboratory (B4/220) on Monday-Friday only.

Collection Container: Preferred: Green top (with sodium heparin anticoagulant)

Collection Volume: Preferred: 1-2 mL blood or 0.5-1.0 mL bone marrow

Sample Analyzed: Whole Blood or Bone Marrow

Specimen Transport: Transport specimen to UWHC Core Laboratory (B4/220) at room temperature. Transport with coolant pack during hot weather (> 85F).

Unacceptable Criteria: Bone marrow/blood that is clotted or hemolyzed

Stability: Ambient: 24 hours
Refrigerated: Not acceptable
Frozen: Not acceptable


Interpretation

Interpretation provided with results.

Test Limitations:

Reference range for false positive is 0-5.2% for gain of signal.  Failure to identify an abnormal clone by FISH does not rule out the presence of other abnormalities in the specimen.

 

Additional Information:

If FISH assay is not performed in conjunction with chromosome analysis there is an additional charge for processing the specimen.

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