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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: Varicella-Zoster Ab, IgG

Test Code(s): VZVIGG / VZIGG

CPT Code(s): 86787

Methodology: ELISA

Clinical Significance: The intent of the test system together with other clinical information is to aid in the determination of immune status, and/or aid in the diagnosis of VZV (Varicella-Zoster Virus).

Days Performed: Three times per week.

Turnaround Time: Routine: Up to 4 days


Specimen Requirements

Specimen: Blood

Collection Container: Preferred: Red cap with yellow ring (SST)
Also Acceptable: Red top

Collection Volume: Preferred: 1 mL
Pediatrics: 1 mL

Sample Analyzed: Serum

Volume Required: Preferred: 0.5 mL
Pediatrics: 0.3 mL

Specimen Processing: Centrifuge.  Transfer cell-free serum to plastic vial.  Refrigerate.

Specimen Transport: Transport specimen to the laboratory. Transport with coolant pack if coming from outreach or satellite lab locations.

Unacceptable Criteria: Grossly hemolyzed/lipemic, heat-treated serum, microbially contaminated and serum containing heavily-visible particulate.

Stability: Ambient: 8 hours
Refrigerated: 14 days
Frozen: 3 months at 20C or greater


Interpretation

Negative: No detectable IgG antibodies to VZV.  Patient is presumed to be non-immune and is susceptible to a primary infection.
Equivocal: Immune status cannot be determined.  If clinically warranted, a second sample should be taken at least fourteen days after the first.
Positive: Reactive for IgG antibodies to VZV, indicating a current or past varicella-zoster infection.  A positive IgG antibody level in the absence of current clinical symptoms indicates immunity to VZV.

 

All equivocal test results will be repeated within two working days.

VZV
VARICELLA ZOSTER VIRUS
VZ VIRUS

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