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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: Varicella-Zoster Ab, IgG

Test Code(s): VZVIGG / VZIGG

CPT Code(s): 86787

Methodology: ELISA

Clinical Significance: The intent of the test system together with other clinical information is to aid in the determination of immune status, and/or aid in the diagnosis of VZV (Varicella-Zoster Virus).

Days Performed: Three times per week.

Turnaround Time: Routine: Up to 4 days

Specimen Requirements

Specimen: Blood

Collection Container: Preferred: Red cap with yellow ring (SST)
Also Acceptable: Red top

Collection Volume: Preferred: 1 mL
Pediatrics: 1 mL

Sample Analyzed: Serum

Volume Required: Preferred: 0.5 mL
Pediatrics: 0.3 mL

Specimen Processing: Centrifuge.  Transfer cell-free serum to plastic vial.  Refrigerate.

Specimen Transport: Transport specimen to the laboratory. Transport with coolant pack if coming from outreach or satellite lab locations.

Unacceptable Criteria: Grossly hemolyzed/lipemic, heat-treated serum, microbially contaminated and serum containing heavily-visible particulate.

Stability: Ambient: 8 hours
Refrigerated: 14 days
Frozen: 3 months at 20C or greater


Negative: No detectable IgG antibodies to VZV.  Patient is presumed to be non-immune and is susceptible to a primary infection.
Equivocal: Immune status cannot be determined.  If clinically warranted, a second sample should be taken at least fourteen days after the first.
Positive: Reactive for IgG antibodies to VZV, indicating a current or past varicella-zoster infection.  A positive IgG antibody level in the absence of current clinical symptoms indicates immunity to VZV.


All equivocal test results will be repeated within two working days.


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