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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: FISH- Isochromosome 17q

Test Code(s): 870F53 / HC870F53

CPT Code(s): 88271, 88275

Clinical Significance: To detect isochromosome 17q associated with acute and chronic myeloid leukemia, acute lymphoid leukemia and chronic lymphoid leukemia, and Hodgkin and non-Hodgkin lymphomas. Aids in diagnosis of hematologic disorders and for monitoring disease after treatment or bone marrow transplant.

Testing Site: Testing will be sent to an approved reference laboratory.

Days Performed: Mon-Sat.

Turnaround Time: Routine: 3 - 5 days.


Specimen Requirements

Specimen: Blood or bone marrow

Collection Instructions: Blood or bone marrow must be received and processed by WSLH within 24 hours of collection. Specimen must be received in UWHC Core Laboratory (B4/220) on Monday-Friday only.

Collection Container: Preferred: Green top (with sodium heparin anticoagulant)

Collection Volume: Preferred: 1-2 mL blood or 0.5-1.0 mL bone marrow

Specimen Transport: Transport specimen to UWHC Core Laboratory (B4/220) at room temperature (may transport with coolant during hot, >85 weather).

Unacceptable Criteria: Whole blood or bone marrow that is clotted or frozen.  Plasma and serum are not acceptable.

Stability: Ambient: 24 hours
Refrigerated: Not acceptable
Frozen: Not acceptable


Interpretation

Interpretation provided with results.

Test Limitations:

Failure to identify an abnormal clone by FISH does not rule out the presence of other abnormalities in the specimen.

Deletion 17p, p53 tumor suppressor gene

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