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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: Cyclic Citrullinated Peptide Ab, IgG

Test Code(s): CCPIGG / XCCP

CPT Code(s): 86200

Methodology: Quantitative Enzyme Immunoassay

Clinical Significance: Studies have shown that detection of antibodies to CCP may predict the eventual development into RA when found in undifferentiated arthritis and is a marker of erosive disease in RA. The sensitivity of anti-CCP has been shown to be comparable to RF(50-75%) with a higher specificity(90-95%).

Days Performed: Mon-Fri, dayshift - day varies.

Turnaround Time: Stat: Not available stat.
Routine: 5 - 7 working days.

Specimen Requirements

Specimen: Blood

Patient Preparation: None

Collection Container: Preferred: Red top
Also Acceptable: Red cap with yellow ring (SST)

Collection Volume: Preferred: 3 mL
Pediatrics: 1 mL

Sample Analyzed: Serum

Volume Required: Preferred: 1 mL
Pediatrics: 0.3 mL

Specimen Processing: Centrifuge. Transfer cell free serum to plastic vial.  Refrigerate.

Specimen Transport: Transport specimen to UWHC Core Laboratory (B4/220). Transport with coolant pack if coming from UWHC Satellite lab or outreach location.

Unacceptable Criteria: Serum is microbially contaminated, heat-treated, grossly hemolyzed, lipemic, turbid or has added azide or other preservatives

Stability: Ambient: 48 hours
Refrigerated: 14 days
Frozen: 3 months at -20 C or lower. Note: Avoid repeat freeze and thaw.


Reference Interval:

0 days and up: 0-19 Units


0-19 Units   


20-39 Units   

Weak Positive

40-59 Units

Moderately Positive

60 or more Units   

Strongly Positive


Anti Citrullinated Antibody
Anti Citrulline
Anti-CCP (Cyclic Citrullinated Peptide)
Anti-Citrullinated Ab
Anti-Citrullinated Antibody
Anti-Citrulline Antibody
Anti-Cyclic Citrullinated Peptide (CCP)
CCP (Cyclic Citrullinated Peptide)
Citrullinated Ab
Citrullinated Antibody
Cyclic Citrullinated Peptide Antibodies

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