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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: Human Papilloma (HPV) Genotyping, 16/18

Test Code(s): HPVGEN / HCHPVGEN

CPT Code(s): 87621

Test Description: Test Component:

 

Pap and HPV Testing FAQ's


Methodology: Invader Assay

Clinical Significance: Detection of HPV16 and HPV18

HPV Genotyping should only be ordered within the Pap order as a reflex test. Current ASCCP HPV triage recommendations are based on reflexing for HPV Genotyping off of the Pap result, HPV result, and patient's age. Our lab staff triage for HPV Genotyping is based on your order request within the Pap order and the ASCCP criteria. See the Pap and HPV Testing FAQ's link in test description above.

Days Performed: Once a week.

Turnaround Time: Routine: 10 days.


Specimen Requirements

Specimen: See collection instructions.

Collection Instructions: See instructions for Cytology, ThinPrep Pap Test

Collection Container: Preferred: ThinPrep PreservCyt Solution Vial 20 mL

Collection Volume: Preferred: 20 mL

Volume Required: Preferred: 6 mL

Specimen Transport: Place specimen inside a biohazard bag with the request form in the outside pocket of the bag. Transport specimen to UWHC Core Laboratory (B4/220).

Unacceptable Criteria: Failure to tighten the cap on the PreservCyt vial may cause loss of the specimen.

Stability: Ambient: 18 weeks.Note specimens are retained only 3 weeks following initial High Risk HPV testing.


Interpretation

Report provides interpretation.

Test Limitations:

A Not Detected result does not exclude the possibility of infection with HPV 16 or HPV 18, or any other high risk HPV type (31,33,35,39,45,51,52,56,58,59,66,68).  False negative results may be due to low levels of HPV infected cells, inhibitory substances, inappropriate or inadequate sampling, or insufficient cellular material.  Inadequate specimen collection, processing and storage may invalidate test results. 

 

Virus quantitation is not possible due to the nature of the specimen.

Additional Information:

This test should not be used as the only criterion to form a clinical conclusion; instead, results should be correlated with other test results, patient symptoms and clinical presentation. 

 

This test is approved by the U.S. Food and Drug Administration.

 

human papillomavirus genotyping, HPV16, HPV18

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