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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: HLA DR Locus

Test Code(s): LRDRBS / HCDRB1S (if Pre-Tx) , LRDRBB / HCDRB1B (if Post-Tx)

CPT Code(s): 81376

Test Description: Test Component:

Low-to-mid level resolution HLA Class II DRB1 loci typing. Identifies DR1-18 some at the allele level and some at the group level.

Methodology: Reverse SSO detected by Luminex xMAP (Multi-Analyte Profiling)

Clinical Significance: HLA-DRB1 loci low-to-mid level resolution typing typically used to match donor and recipients for organ transplantation.  Also may be used to identify the presence of HLA-DRB alleles associated with some diseases (specify allele or disease under investigation in the request to assure proper interpretation).

Days Performed: Mon-Fri, dayshift.

Turnaround Time: Stat: Not available stat.
Routine: 5 working days.

Specimen Requirements

Specimen: Blood

Patient Preparation: No transfusions (RBC, WBC, Platelets) within 24 hours prior to collection.

Collection Container: Preferred: Lavender top
Also Acceptable: Yellow top(with ACD-A/B anticoagulant)

Collection Volume: Preferred: 4 mL
Pediatrics: 1 mL

Volume Required: Preferred: 4 mL
Pediatrics: 1 mL

Specimen Transport: Transport whole blood specimen at room temperature or refrigerated to UWHC Core Laboratory (B4/220) immediately.

Stability: Ambient: 7 days
Refrigerated: 3 weeks
Frozen: Not acceptable


A written interpretive report will be provided.

Additional Information:

If sufficient DNA can be extracted from specimen, the excess DNA will be held by the laboratory for approximately six months for additional high-resolution HLA typing.


This test was developed and its performance characteristics determined by this laboratory.  It has not been cleared or approved by the US Food and Drug Administration.  The FDA has determined that such clearance or approval is not necessary.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.  This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) as qualified to perform high complexity clinical laboratory testing.

class II class 2 disease hla typing drb

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