UW Hospital and Clinics Lab Test Directory
| Test Name: |
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Tripeptidyl Peptidase 1 WBC (CLN2)
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| Test Code(s): |
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CLN2 / HCCLN2
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| CPT Code(s): |
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82657
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| Methodology: |
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Enzymatic
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| Clinical Significance: |
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Useful in diagnosis of NCL due to TPP deficiency in a symptomatic patient, primarily the infantile-onset form. This test is not for carrier testing.
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| Testing Site: |
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Testing will be sent to an approved reference laboratory.
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| Days Performed: |
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Once a week.
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| Turnaround Time: |
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Routine: 8 - 12 days.
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Specimen Requirements
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| Specimen: |
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Blood
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| Collection Instructions: |
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This blood must be received and processed by performing lab within 24 hours of collection. Blood must be received by the UWHC Core Laboratory Monday-Thursday before 1200. Filter paper blood spots may be submitted if shipping will be delayed or if 5-10 mL blood cannot be drawn. Filter paper may be obtained from UWHC Client Services (B4/220) at 608.263.7060.
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| Collection Container: |
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Preferred: Yellow top(with ACD-A/B anticoagulant)
Also Acceptable:
Green top (with sodium heparin anticoagulant)
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| Collection Volume: |
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Preferred: 10 mL
Pediatrics: 5 mL
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| Sample Analyzed: |
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Whole Blood
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| Volume Required: |
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Preferred: 10 mL
Pediatrics: See collection instructions.
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| Specimen Transport: |
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Transport specimen to UWHC Core Laboratory (B4/220).
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| Unacceptable Criteria: |
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Spun or frozen blood.
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| Stability: |
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Ambient: 24 hours
Refrigerated: Not acceptable
Frozen: Not acceptable
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Interpretation
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Interpretation provided with results.
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NCL Batten TPP Neuronal Ceroid Lipofucinosis TPP1
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