| Test Name: |
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Levetiracetam
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| Test Code(s): |
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KEPPRA / HCKEPPRA
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| Methodology: |
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High Performance Liquid Chromatography
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| Clinical Significance: |
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Anticonvulsant
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| Days Performed: |
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Mon-Fri, dayshift.
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| Turnaround Time: |
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Stat: Not available stat.
Routine: 48 hours.
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Specimen Requirements
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| Specimen: |
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Blood
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| Collection Instructions: |
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Collect specimen for trough level prior to next dose.
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| Collection Container: |
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Preferred: Red top
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| Collection Volume: |
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Preferred: 3 mL
Pediatrics: 1 mL
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| Sample Analyzed: |
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Serum
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| Volume Required: |
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Preferred: 1 mL
Pediatrics: 0.5 mL
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| Specimen Processing: |
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Centrifuge. Transfer serum to clean tube. Refrigerate.
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| Specimen Transport: |
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Transport specimen to UWHC Core Laboratory (B4/220). Transport with coolant pack if coming from outreach location.
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| Unacceptable Criteria: |
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Specimens collected in red cap with yellow ring (SST) trubes are not acceptable.
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| Stability: |
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Refrigerated: 2 weeks
Frozen: 1 year
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Interpretation
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Interpretive Guidelines:
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Therapeutic concentrations of levetiracetam have not been established. Dosing should be guided by clinical response. In general, a serum concentration of 5 - 30 mcg/mL is considered effective for individuals 18 years old and up.
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| Additional Information: |
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A result of "BELOW" indicates that the result is below the method detection limit of 3 mcg/mL.
This test was developed and its performance characteristics determined by the UWHC Clinical Laboratories. This test meets the standards for clinical testing. This test should not be regarded as investigational or for research use. The US Food and Drug Administration (FDA) has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.
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