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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: STR Engraftment Unseparated Lineages, Bone Marrow

Test Code(s): STREBM / HCSTREBM

CPT Code(s): 81267

Methodology: PCR

Clinical Significance: Typically used to assess proportions of donor and recipient derived nucleated cells post stem cell transplant or in cases of suspected graft-vs-host disease.

Days Performed: Wed.

Turnaround Time: Routine: 10 days.


Specimen Requirements

Specimen: Bone marrow aspirate

Collection Container: Preferred: Lavender top

Collection Volume: Preferred: 1 mL
Pediatrics: 1 mL

Sample Analyzed: Bone Marrow Aspirate

Volume Required: Preferred: 1 mL
Pediatrics: 0.6 mL

Specimen Transport: Transport specimen to UWHC Core Laboratory (B4/220).

Stability: Ambient: 7 days
Refrigerated: 3 weeks
Frozen: Not acceptable


Interpretation

 

 >95% Donor DNA:  Predominantly Donor
 < 5% Donor DNA:  Predominantly Recipient
 5-95% Donor DNA:  Donor/Recipient Chimeric

    

Additional Information:

Test requires pre-transplant DNA samples on file in the laboratory for recipient and donor.

 

The performance characteristics of this test were validated by UWHC Clinical Laboratories. The U.S. Food and Drug Administration (FDA) has not approved or cleared this test; however, FDA approval or clearance is currently not required for clinical use of this test. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. The UWHC Clinical Laboratories is authorized under Clinical Laboratory Improvement Amendments (CLIA) to perform high-complexity testing.

Engraftment Chimeric studies BMSTWB bone marrow

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