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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: FISH- CLL Panel

Test Code(s): SLHCLL / HCSLHCLL

CPT Code(s): 88271 x5, 88275 x4

Test Description: Test Component:

870F40- 11q22 deletion/duplication, FISH, ATM gene

870F43- Deletion 13q14, FISH, D13S319

870F47- Deletion 17p13.1, FISH, TP53

870F51- Trisomy 12, FISH, D12Z3


Methodology: Fluorescence In Situ Hybridization (FISH)

Clinical Significance: Aids in diagnosis of hematologic disorders and for monitoring disease after treatment or bone marrow transplant.

Testing Site: Testing will be sent to an approved reference laboratory.

Days Performed: Mon-Sat.

Turnaround Time: Routine: 3 - 5 days.


Specimen Requirements

Specimen: Blood or bone marrow

Collection Instructions: Blood or bone marrow must be received and processed by WSLH within 24 hours of collection. Specimen must be received in UWHC Core Laboratory (B4/220) on Monday-Friday only.

Collection Container: Preferred: Green top (with sodium heparin anticoagulant)

Collection Volume: Preferred: 2-3 mL blood or 0.5-1.0 mL bone marrow

Sample Analyzed: Whole Blood or Bone Marrow

Specimen Transport: Transport specimen at room temperature to UWHC Core Laboratory (B4/220). Transport with coolant pack during hot weather (>85F).

Unacceptable Criteria: Bone marrow/blood that is clotted or hemolyzed.

Stability: Ambient: 24 hours
Refrigerated: Not acceptable
Frozen: Not acceptable


Interpretation

Interpretation provided with results.

Test Limitations:

Failure to identify an abnormal clone by FISH does not rule out the presence of other abnormalities in the specimen.

Additional Information:

If FISH assay is not performed in conjunction with chromosome analysis there is an additional charge for processing the specimen.

870F40- 11q22 deletion/duplication, FISH, ATM gene; 870F43- Deletion 13q14, FISH, D13S319; 870F47- Deletion 17p13.1,  FISH, TP53; 870F51- Trisomy 12, FISH, D12Z3 chronic lymphocytic

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