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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: FISH- AML Panel


CPT Code(s): 88271 x 10, 88275 x 5

Test Description: Test Component:

882F80-CBFB Rearrrangement,inv(16)(p13.1q22), FISH

870F45-Deletion 5q31, FISH EGR1

870F42-Deletion 7q31,Monosomy 7,D7S522

881F63-ETO/AML1 Fusion,t(8;21)q22;q22), FISH

882F84-MLL Rearrangement,FISH


Look up individual test components. 

Methodology: Fluorescence In Situ Hybridization (FISH)

Clinical Significance: Aids in diagnosis of hematologic disorders and for monitoring disease after treatment or bone marrow transplant.

Testing Site: Testing will be sent to an approved reference laboratory.

Days Performed: Mon-Sat.

Turnaround Time: Routine: 4 - 7 days.

Specimen Requirements

Specimen: Blood or bone marrow

Collection Instructions: Blood or bone marrow must be received and processed by WSLH within 24 hours of collection. Specimen must be received in UWHC Core Laboratory (B4/220) on Monday-Friday only.

Collection Container: Preferred: Green top (with sodium heparin anticoagulant)

Collection Volume: Preferred: 2-3 mL blood or 0.5-1.0 mL bone marrow

Sample Analyzed: Whole Blood or Bone Marrow

Specimen Transport: Transport specimen to UWHC Core Laboratory (B4/220)at room temperature. Transport with coolant pack during hot weather (> 85F).  

Unacceptable Criteria: Bone marrow/blood that is clotted or hemolyzed

Stability: Ambient: 24 hours
Refrigerated: Not acceptable
Frozen: Not acceptable


Interpretation provided with results.

Test Limitations:

The translocation partner chromosome cannot be determined by this test.

Failure to identify an abnormal clone by FISH does not rule out the presence of other abnormalities in the specimen.


Additional Information:

If FISH assay is not performed in conjunction with chromosome analysis there is an additional charge for processing the specimen.

882F80-CBFB Rearrrangement,inv(16)(p13.1q22),FISH; 870F45-Deletion 5q31, FISH EGR1; 870F42-Deletion 7q31,Monosomy 7,D7S522; 881F63-ETO/AML1 Fusion,t(8;21)q22;q22),FISH; 882F84-MLL Rearrangement,FISH acute myelocytic

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