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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: FISH- Myeloma Panel

Test Code(s): SLHMYL / HCSLHMYL

CPT Code(s): 88271 x 12, 88275 x 7

Test Description: Test Component:

870F40- 11q22 deletion/duplication, FISH, ATM gene

881F62- CCND1/IgH Fusion, t(11;14)(q13;q32), FISH

870F43- Deletion 13q14, FISH, D13S319

870F47- Deletion 17p13.1, FISH, TP53

881F69- FGFR3/IgH Fusion, t(4;14)(p16;q32), FISH

881F70- IGH/MAF Fusion, t(14;16)(q32'q23), FISH

882F82- IGH Rearrangement, FISH


Methodology: Fluorescence In Situ Hybridization (FISH)

Clinical Significance: Aids in diagnosis of hematologic disorders and for monitoring disease after treatment or bone marrow transplant.

Testing Site: Testing will be sent to an approved reference laboratory.

Days Performed: Mon-Sat.

Turnaround Time: Routine: 3 - 5 days.


Specimen Requirements

Specimen: Blood or bone marrow

Collection Instructions: Blood or bone marrow must be received and processed by WSLH within 24 hours of collection. Specimen must be received in UWHC Core Laboratory (B4/220) on Monday-Friday only.

Collection Container: Preferred: Green top (with sodium heparin anticoagulant)

Collection Volume: Preferred: 2-3 mL blood or 0.5-1.0 mL bone marrow

Sample Analyzed: Whole Blood or Bone Marrow

Specimen Transport: Transport specimen at room temperature to UWHC Core Laboratory (B4/220). Transport with coolant pack during hot weather (>85F).
  

Unacceptable Criteria: Bone marrow/blood that is clotted or has been frozen.

Stability: Ambient: 24 hours
Refrigerated: Not acceptable
Frozen: Not acceptable


Interpretation

Interpretation provided with results.

Test Limitations:

Failure to identify an abnormal clone by FISH does not rule out the presence of other abnormalities in the specimen.

 

Additional Information:

If FISH assay is not performed in conjunction with chromosome analysis there is an additional charge for processing the specimen.

870F40- 11q22 deletion/duplication, ATM gene; 881F62-CCND1/IgH Fusion, 7(11;14)q13;q32); 870F43-D eletion 13q14, D13S319, LAMP1; 870F47-D eletion 17p13.1, TP53, P53, FISH, CLL;881F69- FGFR3/IgH Fusion, t(4:14)(p16:q32),FISH; 881F70- IGH/MAF Fusion, t(14;16)(q32;q23),FISH; 882F82-IGH Rearrangement, FISH

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