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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: FISH- API2/MALT Fusion, t(11;18)(q21:q21)

Test Code(s): 881F60 / HC881F60

CPT Code(s): 88271x2, 88275

Methodology: Fluorescence In Situ Hybridization (FISH)

Clinical Significance: To detect the presence of specific fusions of chromosomes associated with lymphoma of mucosa associated lymphoid tissue. Aids in diagnosis of hematologic disorders and for monitoring disease after treatment or bone marrow transplant.

Testing Site: Testing will be sent to an approved reference laboratory.

Days Performed: Mon-Sat.

Turnaround Time: Routine: 3 - 5 days.


Specimen Requirements

Specimen: Blood or bone marrow

Collection Instructions: This blood must be received and processed by WSLH within 24 hours of collection.  Blood must be received by the Core Laboratory on  Monday-Friday.

Collection Container: Preferred: Green top (with sodium heparin anticoagulant)

Collection Volume: Preferred: 1-2 mL blood or 0.5-1.0 mL bone marrow

Sample Analyzed: Whole Blood or Bone Marrow

Specimen Transport: Transport specimen to UWHC Core Laboratory (B4/220) at room temperature. Transport with coolant pack during hot weather (> 85 F).

Unacceptable Criteria: Bone marrow/blood that is clotted or hemolyzed.

Stability: Ambient: 24 hours
Refrigerated: Not acceptable
Frozen: Not acceptable


Interpretation

Interpretation provided with results.

Test Limitations:

Failure to identify an abnormal clone by FISH does not rule out the presence of other abnormalities in the specimen.

Additional Information:

If  FISH assay is not performed in conjunction with chromosome analysis there is an additional charge for processing the specimen.

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