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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: Copper, Liver, Tissue

Test Code(s): CULIVR / HCCULIVR

Test Description: Link: http://www.mayomedicallaboratories.com/test-catalog/Overview/8687

Testing Site: Testing will be sent to an approved reference laboratory.


Specimen Requirements

Collection Instructions: Call UWHC Core Laboratory at (608)263-7060 to obtain Mayo metal-free specimen vials (blue label, not sterile). Obtain biopsy tissue and place in the Mayo metal-free vial. Two specimens are always obtained when a liver copper determination is ordered.  One specimen is for liver copper determination. This specimen can also be used for a liver iron determination, if needed. The second specimen is for morphology determination (for container and handling, see laboratory test directory, test name: Histopathology).

The following procedure for specimen handling should be followed precisely as it is intended to control trace metal contamination and maintain specimen quality for the liver copper determination.

A minimum of 2 mg of liver tissue is required for the copper determination.  This is typically a piece of tissue from a 14-gauge needle biopsy at least 0.5 cm long.  If an 18 gauge needle is used, the tissue must be at least 1 cm in length.  Expel each tissue from the biopsy needle directly into the appropriate specimen vial.  The vials are not sterile so when the biopsy needle touches the vial, it should no longer be considered sterile.

1. To avoid trace metal contamination, biopsy tissue for the liver copper determination is placed directly into a clean empty Mayo vial. The tissue should not touch any other surface.
2. A stainless steel forceps or scalpel can be used to assist the transfer of the sample from the needle, if needed.

Alternate Container (not recommended): Any specimen vial other than a Mayo metal-free vial should be all plastic, rinsed with Type 1 (18 mega ohm resistance) deionized water and dried with clean air.

The paraffin embedded tissue is usually an acceptable second choice for the liver copper determination unless the block is processed with a stain. However, the 18-gauge needle produces a specimen that is thin and fragile and difficult to remove from paraffin.  Also, a paraffin block can be acceptable if not more than 1 or 2 cuts have been made to it for slides.  If sent, the paraffin blocks will be returned from Mayo to the UWHC Surgical Pathology Lab two weeks after the analysis is complete unless requested earlier.

Specimen Transport: Transport along with a request form to UWHC Core Laboratory (B4/220) immediately.  Transport with a coolant pack if coming from an outreach location.  Ship refrigerated to referral lab.


Interpretation

Additional Information:

This test is for quantitative copper only. A second specimen should be collected for qualitative staining in UWHC Surgical Pathology.

Biopsy,
Liver Biopsy
Wilson's Disease,
Trace Metals,
Hepatic copper,
Cu Liver Tissue,
Copper Tissue Liver,
Metals Tissue,
Trace Metals Tissue,

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