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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: Cryoglobulin, Quantitative


CPT Code(s): 82595

Methodology: Visual inspection for formation of Cryoglobulin. Cryocrit calculation if positive.

Clinical Significance: The Cryocrit is primarily intended for following a patient with previously defined and quantitated cryoglobulins.  The Cryocrit may consist of cryoglobulins, fibrins or mixtures of cryoglobulins and fibrin.

Testing Site: Testing will be sent to an approved reference laboratory.

Turnaround Time: Routine: 4 - 7 days.

Specimen Requirements

Specimen: Blood

Patient Preparation: Patient must fast for at least 6 hours prior to specimen collection. The patient may only have water or black coffee during the fasting period

Collection Instructions: This blood must be sent by overnight courier to arrive at the performing laboratory within 72 hours of draw time.  Blood must be received in UWHC Client Services (B4/220) by 1200 Monday-Wednesday ONLY.
Keep specimen at 37C by wrapping a hot pack (infant heel warmer) around the tube immediately after collection. BEFORE COLLECTING SPECIMEN, pre-warm a red top tube (e.g. in an infant heel warmer). Have another infant heel warmer on hand to deliver the blood to the laboratory after collection. Transport specimen to UWHC Core Laboratory (B4/220) within 10 minutes of collection. Contact laboratory if unable to assure delivery within 10 minutes.

Processed samples must arrive at UWHC Core Lab by 1200H Monday- Wednesday from outside laboratories.

Collection Container: Preferred: Red top

Collection Volume: Preferred: 9 mL
Pediatrics: 6 mL

Sample Analyzed: Serum

Volume Required: Preferred: 3 mL
Pediatrics: 2 mL

Specimen Processing: IMPORTANT: Keep whole blood specimen at 37C during entire processing procedure.  

Specimen Transport: Transport whole blood specimen to UWHC Core Laboratory (B4/220) within ten minutues of collection-keep specimen at 37C by wrapping tube in a hot pack (infant heel warmer).
Transport processed specimen to UWHC Core Laboratory (B4/220) at room temperature if coming from outreach location.  

Unacceptable Criteria: Icteric specimens.

Stability: Ambient: 3 days off cells
Refrigerated: Not acceptable
Frozen: Not acceptable


Reference Interval:

Cryoglobulin Qualitative:   Negative


%Cryocrit%:                    None Detected

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