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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: Galactomannan, CSF

Test Code(s): MISC / RMISC

CPT Code(s): 87305

Methodology: Enzyme Immunoassay

Clinical Significance: Aids in early diagnosis of invasive aspergillosis.

Testing Site: Testing will be sent to an approved reference laboratory.

Days Performed: Mon-Fri.


Specimen Requirements

Specimen: See collection instructions.

Collection Instructions: Collect minimum of 2 mL of CSF in a numbered specimen tube from a sterile disposable lumbar puncture tray.

Collection Container: Preferred: Sterile screw cap container

Volume Required: Preferred: 2 mL
Pediatrics: 0.8 mL

Specimen Processing: Centrifuge bloody CSF specimen. Transfer cell-free CSF to clear plastic vial. Freeze CSF.

Specimen Transport: Transport specimen to UWHC Core Laboratory (B4/220). Transport with coolant pack if coming from outreach location. If frozen, transport on dry ice.

Unacceptable Criteria: Urine is NOT an acceptable specimen type for this test.

Stability: Ambient: Not acceptable
Refrigerated: 48 hours
Frozen: Okay


Interpretation

Reference Interval:

CSF: < 0.5

 

Results are reported as numerical values (Index) which are interpreted as positive or negative.

Test Limitations:

Piperacillin-tazobactam (Zosyn) has been shown to cause positive interference. Other genera of fungi such as Penicillium, Alternaria, and Paecilomyces have shown reactivity with the antibody used in this assay. This assay has not been evaluated for use with plasma or other sample types such as urine. The performance of this assay has not been evaluated with neonate samples. The use of anti-fungal therapy in some patients may result in reduced sensitivity with this assay.

Platelia Aspergillus Antigen EIA
Aspergillosis

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