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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: Chromosome Analysis, Prenatal, Amniotic Fluid

Test Code(s): MISC / RMISC

CPT Code(s): 88235,88267,88280

Clinical Significance: Chromosome analysis for pregnancies at risk due to maternal age, abnormal AFP or triple screen, ultrasound abnormalities, parental translocation carrier, previous trisomy, previous history of abortion or infertility, past x-ray exposure, etc

Testing Site: Testing will be sent to an approved reference laboratory.

Days Performed: Mon-Sat.

Turnaround Time: Routine: 7 - 10 days.


Specimen Requirements

Specimen: Amniotic Fluid

Collection Instructions: Collect by physician using ultrasound.
Amniotic fluid must be received and processed by WSLH within 24 hours of collection.  Amniotic fluid must be received by UWHC Core Laboratory Monday-Friday.

Collection Container: Preferred: Sterile screw cap container

Collection Volume: Preferred: 15 - 30 mL

Specimen Transport: Transport specimen to UWHC Core Laboratory (B4/220).  

Stability: Frozen: Not acceptable


Interpretation

Expected Results:

46,XX or 46,XY; Apparently normal karyotype, photograph of a representative karyotype included with report.

Additional Information:

In situ and flask cell cultures with analysis of 12-15 independent colonies with G-banding, two karyotypes; additional cells, karyotypes and/or other banding procedures are performed if indicated by initial results. Also includes Alpha Fetoprotein (AFP) determination and acetylcholinesterase (AChE) when appropriate. If additional banding is indicated, will perform extended banding, Q-banding, C-banding, N-banding and/or DNA probes; if initial results suggest mosaicism, an additional 15 colonies and/or 50 cells will be analyzed; in case of unusual variants it may be necessary to study parents' blood chromosomes to clarify fetal chromosome results. This is done at no additional charge when needed for the diagnosis.

cytogenetics

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