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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: Chromosome Analysis, Prenatal, Amniotic Fluid

Test Code(s): MISC / RMISC

CPT Code(s): 88235,88267,88280

Clinical Significance: Chromosome analysis for pregnancies at risk due to maternal age, abnormal AFP or triple screen, ultrasound abnormalities, parental translocation carrier, previous trisomy, previous history of abortion or infertility, past x-ray exposure, etc

Testing Site: Testing will be sent to an approved reference laboratory.

Days Performed: Mon-Sat.

Turnaround Time: Routine: 7 - 10 days.

Specimen Requirements

Specimen: Amniotic Fluid

Collection Instructions: Collect by physician using ultrasound.
Amniotic fluid must be received and processed by WSLH within 24 hours of collection.  Amniotic fluid must be received by UWHC Core Laboratory Monday-Friday.

Collection Container: Preferred: Sterile screw cap container

Collection Volume: Preferred: 15 - 30 mL

Specimen Transport: Transport specimen to UWHC Core Laboratory (B4/220).  

Stability: Frozen: Not acceptable


Expected Results:

46,XX or 46,XY; Apparently normal karyotype, photograph of a representative karyotype included with report.

Additional Information:

In situ and flask cell cultures with analysis of 12-15 independent colonies with G-banding, two karyotypes; additional cells, karyotypes and/or other banding procedures are performed if indicated by initial results. Also includes Alpha Fetoprotein (AFP) determination and acetylcholinesterase (AChE) when appropriate. If additional banding is indicated, will perform extended banding, Q-banding, C-banding, N-banding and/or DNA probes; if initial results suggest mosaicism, an additional 15 colonies and/or 50 cells will be analyzed; in case of unusual variants it may be necessary to study parents' blood chromosomes to clarify fetal chromosome results. This is done at no additional charge when needed for the diagnosis.


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