| Test Name: |
|
T pallidum by TP-PA
|
|
|
|
|
|
|
| Test Code(s): |
|
TPPA / XMHATP
|
|
|
|
|
|
|
| CPT Code(s): |
|
86780
|
|
|
|
|
|
|
| Methodology: |
|
Gelatin Particle Agglutination
|
|
|
|
|
|
|
| Clinical Significance: |
|
Confirmatory test for reactive non-treponemal screening tests (RPR or VDRL) for syphilis.
|
|
|
|
|
|
|
| Testing Site: |
|
Testing will be sent to an approved reference laboratory.
|
|
|
|
|
|
|
| Days Performed: |
|
Mon-Fri.
|
|
|
|
|
|
|
| Turnaround Time: |
|
Routine: 2 - 3 days.
|
|
|
|
Specimen Requirements
|
|
|
|
| Specimen: |
|
Blood
|
|
|
|
|
|
|
| Collection Container: |
|
Preferred: Red top
|
|
|
|
|
|
|
| Collection Volume: |
|
Preferred: 4 mL
Pediatrics: 3 mL
|
|
|
|
|
|
|
| Sample Analyzed: |
|
Serum
|
|
|
|
|
|
|
| Volume Required: |
|
Preferred: 2 mL
Pediatrics: 1 mL
|
|
|
|
|
|
|
| Specimen Processing: |
|
Centrifuge. Transfer cell free serum to plastic vial. Refrigerate.
|
|
|
|
|
|
|
| Specimen Transport: |
|
Transport specimen to UWHC Core Laboratory (B4/220). Transport with coolant pack if coming from outreach location.
|
|
|
|
|
|
|
Interpretation
|
|
|
|
|
Interpretive Guidelines:
|
|
A reactive TP-PA test result confirms the reactivity of the nontreponemal test (VDRL or RPR) used as the initial test for syphilis. A reactive TP-PA result suggests current or past infection with pathogenic treponemes. A reactive TP-PA test may also support the diagnosis of late syphilis or long-standing late-latent syphilis in the small proportion of such cases in which the nontreponemal test has become non-reactive, but infection is suspected because of the clinical presentation or a history consistent with syphilis infection.
|
|
|
|
|
|
|
