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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: Mycophenolic Acid

Test Code(s): MPA / HCMPA

CPT Code(s): 80180

Methodology: Liquid Chromatography

Clinical Significance: Immunosuppressive

Days Performed: Mon-Fri, dayshift.

Turnaround Time: Stat: Not available stat.
Routine: 48 hours.


Specimen Requirements

Specimen: Blood

Collection Instructions: Draw trough specimen just prior to administration of next dose.

Collection Container: Preferred: Red top
Also Acceptable: Lavender top

Collection Volume: Preferred: 4 mL
Pediatrics: 2 mL

Sample Analyzed: Serum or plasma

Volume Required: Preferred: 2 mL
Pediatrics: 0.7 mL

Specimen Processing: Centrifuge. Transfer cell-free serum/plasma to plastic vial. Refrigerate. Freeze sample if unable to assay within 24 hours.

Specimen Transport: Transport specimen to UWHC Core Laboratory (B4/220).  Transport with coolant pack if coming from outreach location. Transport frozen serum or plasma on dry ice.

Unacceptable Criteria: Specimens collected in red cap with yellow ring (SST) tubes are not acceptable.

Stability: Ambient: 8 hours
Refrigerated: 24 hours; if on cells - 8 hours
Frozen: 14 days


Interpretation

Interpretive Guidelines:

A definitive therapeutic concentration for Mycophenolic Acid has not been established. Dosing of 2 g/day gives trough values of 1.0-3.5 mcg/mL while 3 g/day gives values up to 5.0 mcg/mL. Trough levels between 2.0 - 4.0 mcg/mL have been suggested to maximize efficacy and minimize adverse effects. (Krumme, Meiser 1997; and Meiser, et al 1998.)

Additional Information:

Result of "BELOW" indicates that the result is below the method detection limit of 0.4 mcg/mL.

 

This test was developed and its performance characteristics determined by the UWHC Clinical Laboratories.  This test meets the standards for clinical testing.  This test should not be regarded as investigational or for research use.  The US Food and Drug Administration (FDA) has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.

Mycophenolate Mofetil MMF CellCept

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