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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: Sirolimus

Test Code(s): SIRO / HCSIRO

CPT Code(s): 80195

Methodology: Immunoassay

Clinical Significance: Immunosuppressive

Days Performed: Daily.

Turnaround Time: Routine: 24 hours.


Specimen Requirements

Specimen: Blood

Patient Preparation: Sirolimus level should be determined on trough specimen collected just prior to administration of the next dose.

Collection Instructions: Collect specimen just before taking next dose.

Collection Container: Preferred: Lavender top

Collection Volume: Preferred: 4 mL
Pediatrics: 0.5 mL

Sample Analyzed: Whole Blood

Specimen Processing: Do NOT centrifuge or separate plasma. SEND WHOLE BLOOD. Refrigerate.

Specimen Transport: Transport specimen at ambient temperature to UWHC Core Laboratory (B4/220).

Stability: Ambient: 7 days
Refrigerated: 7 days
Frozen: 3 months


Interpretation

Interpretive Guidelines:

A definitive therapeutic concentration for sirolimus has not been established. A concentration of 5-15 ng/mL is generally considered to be therapeutic for individuals 18 years old and up.

Critical Calls: View

Additional Information:

The reportable range for sirolimus is 2 - 60 ng/mL. Results of less than 2 ng/ mL will be reported as less than 2 ng/mL.

 

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