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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: Topiramate

Test Code(s): TOPIR / XTOPIR

CPT Code(s): 80201

Methodology: Gas Chromatography

Clinical Significance: Anticonvulsant

Days Performed: Mon-Fri, dayshift.

Turnaround Time: Routine: 24 - 48 hours.

Specimen Requirements

Collection Instructions: Draw blood specimen immediately prior to next dose.  

Collection Container: Preferred: Lavender top
Also Acceptable: Red top

Collection Volume: Preferred: 4 mL
Pediatrics: 2 mL

Sample Analyzed: Plasma

Volume Required: Preferred: 2 mL
Pediatrics: 0.7 mL

Specimen Processing: Centrifuge immediately. Transfer cell free plasma to plastic vial. Refrigerate.

Specimen Transport: Transport specimen to UWHC Core Laboratory (B4/220). Transport with coolant pack if coming from outreach location.

Stability: Ambient: 6 days
Refrigerated: 14 days
Frozen: 14 days


Interpretive Guidelines:

Definitive therapeutic concentration for topiramate has not been established. A single dose study shows peak concentrations range from 1.7-29.0 mcg/mL for doses ranging from 100-1200 mg. Peak level occurs 1.8-4.3 hours after dose. (Reference: D.E. Easterling, et al).

Additional Information:

This test was developed and its performance characteristics determined by the UWHC Clinical Laboratories.  This test meets the standards for clinical testing.  This test should not be regarded as investigational or for research use.  The US Food and Drug Administration (FDA) has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.


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