| Test Name: |
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Topiramate
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| Test Code(s): |
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TOPIR / XTOPIR
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| CPT Code(s): |
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80201
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| Methodology: |
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Gas Chromatography
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| Clinical Significance: |
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Anticonvulsant
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| Days Performed: |
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Mon-Fri, dayshift.
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| Turnaround Time: |
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Routine: 24 - 48 hours.
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Specimen Requirements
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| Collection Instructions: |
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Draw blood specimen immediately prior to next dose.
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| Collection Container: |
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Preferred: Lavender top
Also Acceptable:
Red top
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| Collection Volume: |
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Preferred: 4 mL
Pediatrics: 2 mL
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| Sample Analyzed: |
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Plasma
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| Volume Required: |
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Preferred: 2 mL
Pediatrics: 0.7 mL
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| Specimen Processing: |
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Centrifuge immediately. Transfer cell free plasma to plastic vial. Refrigerate.
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| Specimen Transport: |
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Transport specimen to UWHC Core Laboratory (B4/220). Transport with coolant pack if coming from outreach location.
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| Stability: |
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Refrigerated: 2 weeks
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Interpretation
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Interpretive Guidelines:
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Definitive therapeutic concentration for topiramate has not been established. A single dose study shows peak concentrations range from 1.7-29.0 mcg/mL for doses ranging from 100-1200 mg. Peak level occurs 1.8-4.3 hours after dose. (Reference: D.E. Easterling, et al).
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| Additional Information: |
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This test was developed and its performance characteristics determined by the UWHC Clinical Laboratories. This test meets the standards for clinical testing. This test should not be regarded as investigational or for research use. The US Food and Drug Administration (FDA) has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.
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