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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: Drug Screen, GC/MS, Urine

Test Code(s): TUPNL / HCTUPNL

CPT Code(s): 80100

Test Description: Included In: Procedure Panel: Drug Screen, Urine Comprehensive [HCMSUPNL]

Methodology: Gas Chromatography/Mass Spectrometry

Days Performed: Mon-Fri, dayshift.

Turnaround Time: Routine: 3 - 5 days.

Specimen Requirements

Specimen: Random urine

Collection Instructions: Drugs suspected and known medications should be indicated. The laboratory strongly favors direct communication between the primary physician and the laboratory. Since the drug screen is a search for the presence of an unknown drug, any drug-related patient history communicated to the laboratory will give the analyst a point of direction in the testing of the sample and help expedite return of results.

Collection Container: Preferred: Sterile screw cap container

Collection Volume: Preferred: 25 mL

Sample Analyzed: Urine aliquot

Volume Required: Preferred: 10 mL
Pediatrics: 7 mL

Specimen Transport: Transport specimen to UWHC Core Laboratory (B4/220). Transport with coolant pack if coming from outreach location.

Stability: Ambient: 3 days
Refrigerated: 7 days
Frozen: 1 year


Additional Information:

The Comprehensive Drug Screen simultaneously screens and confirms the presence of over 100 drug substances and drug metabolites in human urine by GC/MS. Report consists of immunoassay screening results and a list of drugs detected and definitively identified by GC/MS. Certain commonly encountered drugs such as morphine, hydromorphone, alprazolam, triazolam, and oxazepam may not be detected by GC/MS because they exhibit poor chromatographic properties. However, these drugs will give presumptive positive immunoassay screening results for the benzodiazepine or opiate classes. Certain toxic substances such as LSD, cannabinoids, alcohols, insecticides, cyaninde, carbon monoxide, salicylic acid, water soluable drugs such as diuretics and many other chemicals and drugs are not detected by this procedure. 


This is a comprehensive test which simultaneously screens for and confirms the presence of the following drugs:

ANALGESICS: antipyrine, ibuprofen, naproxen, orphenadrine, phenylbutazone,  tramadol

ANTIDEPRESSANTS: amitriptyline, bupropion, clomipramine, desipramine, doxepin, fluoxetine, imipramine, maprotiline, mirtazepine, nortriptyline, paroxetine, sertraline, trazodone, venlafaxine

ANTIEPILEPTICS: carbamazepine, felbamate, gabapentin, levetiracetam, phenobarbital, phenytoin, primidone, topiramate, valproic acid, zonisamide ANTIHISTAMINES: chlorpheniramine, diphenhydramine, doxylamine, pheniramine, pyrilamine, tripelennamine

ANTIPSYCHOTICS: chlorpromazine, clozapine, olanzapine, quetiapine, thioridazine

NARCOTICS: codeine, dihydrocodeine, hydrocodone, levorphanol, meperidine, methadone, oxycodone, pentazocine, propoxyphene

SEDATIVES/HYPNOTICS: amobarbital, barbital, butabarbital, butalbital, carisoprodal, chlordiazepoxide, diazepam, ethchlorvynol, flurazepam, meprobamate, metaxalone, methaqualone, midazolam, nordiazepam, pentobarbital, propofol, secobarbital, temazepam, thiopental, zolpidem

SYMPATHOMIMETICS: amphetamine, cathinone, cyclopentamine, ephedrine/pseudoephedrine, methamphetamine, methcathinone, 4-methylaminorex, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxyethylamphetamine, 3,4-methylenedioxymethamphetamine, phentermine

MISCELLANEOUS: amantadine, atropine, cocaine metabolites, cyclobenzaprine, dextromethorphan, diltiazem, disopyramide, fluconazole, lidocaine, phencyclidine, procainamide, propranolol, promethazine, scopolamine, strychnine, theophylline, ticlopidine, trimethoprim, verapamil


NOTE: Please call (608) 263-7029 with any questions regarding drugs not on this list.


This test was developed and its performance characteristics determined by the UWHC Clinical Laboratories.  This test meets the standards for clinical testing.  This test should not be regarded as investigational or for research use.  The US Food and Drug Administration (FDA) has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.


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