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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: Drug Screen, GC/MS, Serum

Test Code(s): TSPNL / HCTSPNL

CPT Code(s): 80304

Methodology: Gas Chromatography/Mass Spectrometry

Days Performed: Mon-Fri, dayshift.

Turnaround Time: Routine: 1 - 3 days.

Specimen Requirements

Specimen: Blood

Collection Instructions: Drugs suspected and known medications should be noted.

Collection Container: Preferred: Red top
Also Acceptable: Royal blue top, Royal blue top (with EDTA anticoagulant)

Collection Volume: Preferred: 9 mL
Pediatrics: 6 mL

Sample Analyzed: Serum

Volume Required: Preferred: 4 mL
Pediatrics: 2 mL

Specimen Processing: Centrifuge. Transfer cell-free serum to a plastic vial. Refrigerate.

Specimen Transport: Transport specimen to UWHC Core Laboratory (B4/220). Transport with coolant pack if coming from outreach location.

Unacceptable Criteria: Specimens collected in red cap with yellow ring (SST) tubes are not acceptable.

Stability: Ambient: 3 days
Refrigerated: 3 days
Frozen: 1 year


Additional Information:

The serum/urine drug screens DO NOT detect all toxic substances. They do not detect alcohols, insecticides, cyanide, LSD, carbon monoxide, marijuana, salicylic acid, water soluble drugs such as diuretics, and many other chemicals and drugs. The serum drug panel will search for the presence of the following drugs:


ANALGESICS: antipyrine, ibuprofen, meperidine, methadone, naproxen, orphenadrine, phenylbutazone, propoxyphene, tramadol

ANTIDEPRESSANTS: bupropion, mirtazepine, paroxetine, sertraline, trazadone, venlafaxine

ANTIEPILEPTICS: carbamazepine, felbamate, lamotrigine, levetiracetam, phenobarbital, phenytoin, primidone, valproic acid, zonisamide ANTIHISTAMINES: chlorpheniramine, diphenhydramine, doxylamine, pyrilamine, tripelennamine

ANTIPSYCHOTICS: chlorpromazine, clozapine, thioridazine

SEDATIVES and HYPNOTICS: amobarbital, barbital, butabarbital, butalbital, carisoprodal, chlordiazepoxide, diazepam, ethchlorvynol, flurazepam, meprobamate, methaqualone, midazolam, nordiazepam, pentobarbital, secobarbital, thiopental

MISCELLANEOUS: chlorzoxazone, cyclizine, cyclobenzaprine, diltiazem, disopyramide, fluconazole, lidocaine, dextromethorphan, procainamide, theophylline, trimethoprim, verapamil.


Depending on dosage and/or route of administration, several other drugs may be detected. These include alprazolam, amitriptyline, clomipromine, cocaine, codeine, desipramine, doxepin, fluoxetine, hydocodone, imipramine, nortriptyline, and oxycodone.


NOTE: Please call (608) 263-7029 with any questions regarding drugs not on this list.


This test was developed and its performance characteristics determined by the UWHC Clinical Laboratories.  This test meets the standards for clinical testing.  This test should not be regarded as investigational or for research use.  The US Food and Drug Administration (FDA) has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.

Toxicology Screen

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