| Test Name: |
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Doxepin
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| Test Code(s): |
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DOX / HCDOX
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| CPT Code(s): |
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80166
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| Test Description: |
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Test Component: Doxepin and metabolite desmethyldoxepin
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| Clinical Significance: |
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Antidepressant
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| Days Performed: |
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Daily, dayshift.
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| Turnaround Time: |
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Stat: 3 hours.
Routine: 24 hours.
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Specimen Requirements
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| Specimen: |
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Blood
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| Collection Instructions: |
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Collect specimen for trough level prior to next dose.
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| Collection Container: |
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Preferred: Red top
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| Collection Volume: |
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Preferred: 4 mL
Pediatrics: 4 mL
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| Sample Analyzed: |
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Serum
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| Volume Required: |
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Preferred: 2 mL
Pediatrics: 1.5 mL
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| Specimen Processing: |
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Centrifuge. Transfer cell-free serum to plastic vial. Refrigerate.
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| Specimen Transport: |
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Transport specimen to UWHC Core Laboratory (B4/220). Transport with coolant pack if coming from outreach location.
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| Unacceptable Criteria: |
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Specimens collected in red cap with yellow ring (SST) tubes are not acceptable.
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| Stability: |
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Refrigerated: 7 days
Frozen: 1 year
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Interpretation
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Interpretive Guidelines:
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| Generally effective therapeutic concentration: |
| 18 years and up: |
doxepin plus
desmethyldoxepin: 150-250 ng/mL
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| Toxic: |
| 18 years and up: |
Total concentration of doxepin
and desmethyldoxepin >500 ng/mL
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| Critical Calls: |
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View
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| Additional Information: |
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Result of "BELOW" indicates that the result is below the method detection limit of 20 ng/mL. The half-life of doxepin in an adult is 12-23 hours.
This test was developed and its performance characteristics determined by the UWHC Clinical Laboratories. This test meets the standards for clinical testing. This test should not be regarded as investigational or for research use. The US Food and Drug Administration (FDA) has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.
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