UW Hospital and Clinics Lab Test Directory
| Test Name: |
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Cyclosporine
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| Test Code(s): |
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CSTD / XCYCA
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| CPT Code(s): |
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80158
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| Methodology: |
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Liquid Chromatography/Mass Spectrometry
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| Clinical Significance: |
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Immunosuppressive
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| Days Performed: |
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Daily, dayshift- Pathology Resident approval is required after hours.
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| Turnaround Time: |
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Routine: 24 hours.
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Specimen Requirements
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| Specimen: |
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Blood
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| Patient Preparation: |
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Cyclosporine level should be determined on trough specimen collected just prior to administration of the next dose.
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| Collection Instructions: |
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Collect specimen just before taking next dose.
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| Collection Container: |
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Preferred: Lavender top
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| Collection Volume: |
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Preferred: 4 mL
Pediatrics: 0.5 mL
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| Specimen Processing: |
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Do NOT centrifuge or separate plasma. SEND WHOLE BLOOD. Refrigerate.
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| Specimen Transport: |
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Transport specimen at ambient temperature to UWHC Core Laboratory (B4/220); avoid freezing.
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| Stability: |
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Ambient: 28 days
Refrigerated: 28 days
Frozen: 6 months
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Interpretation
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Interpretive Guidelines:
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No firm therapeutic range exists for cyclosporine in whole blood and therapeutic ranges vary according to the assay method that is used. Therefore, individual cyclosporine values cannot be used as the sole indicator for making changes in treatment regimen. The cyclosporine whole blood values should be used in conjunction with information available from clinical evaluation and other diagnostic procedures before changes in treatment regimen are made. Each user must establish his or her own ranges based on clinical experience.
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| Critical Calls: |
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View
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| Additional Information: |
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The reportable range for cyclosporine is 10-900 ng/mL. Samples less than 10 ng/mL will be reported as < 10 ng/mL.
This test was developed and its performance characteristics determined by the UWHC Clinical Laboratories. This test meets the standards for clinical testing. This test should not be regarded as investigational or for research use. The US Food and Drug Administration (FDA) has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.
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Sandimmune Neoral Gengraf
CSA
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