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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: Cyclosporine

Test Code(s): CSTD / XCYCA

CPT Code(s): 80158

Methodology: Immunoassay

Clinical Significance: Immunosuppressive

Days Performed: Daily.

Turnaround Time: Routine: 24 hours.


Specimen Requirements

Specimen: Blood

Patient Preparation: Cyclosporine level should be determined on trough specimen collected just prior to administration of the next dose.

Collection Instructions: Collect specimen just before taking next dose.

Collection Container: Preferred: Lavender top

Collection Volume: Preferred: 4 mL
Pediatrics: 0.5 mL

Specimen Processing: Do NOT centrifuge or separate plasma. SEND WHOLE BLOOD. Refrigerate.

Specimen Transport: Transport specimen at ambient temperature to UWHC Core Laboratory (B4/220).

Stability: Ambient: 7 days
Refrigerated: 7 days
Frozen: 3 months


Interpretation

Interpretive Guidelines:

No firm therapeutic range exists for cyclosporine in whole blood and therapeutic ranges vary according to the assay method that is used. Therefore, individual cyclosporine values cannot be used as the sole indicator for making changes in treatment regimen. The cyclosporine whole blood values should be used in conjunction with information available from clinical evaluation and other diagnostic procedures before changes in treatment regimen are made. Each user must establish his or her own ranges based on clinical experience.

Critical Calls: View

Additional Information:

The reportable range for cyclosporine is 25-2000 ng/mL. Samples less than 25 ng/mL will be reported as < 25 ng/mL.

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