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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: Carbamazepine, Unbound

Test Code(s): UMAZE / HCUMAZE

CPT Code(s): 80156, 80157

Test Description: Test Component:

Carbamazepine (total and unbound) are reported.


Methodology: Liquid Chromatography

Clinical Significance: Anticonvulsant

Days Performed: Mon-Fri, dayshift.

Turnaround Time: Routine: 24 hours.


Specimen Requirements

Specimen: Blood

Collection Instructions: Collect serum samples 15-30 minutes prior to morning dose.  

Collection Container: Preferred: Red top

Collection Volume: Preferred: 6 mL
Pediatrics: 3 mL

Sample Analyzed: Serum

Volume Required: Preferred: 2 mL
Pediatrics: 1.5 mL

Specimen Processing: Centrifuge. Transfer cell-free serum to plastic vial. Refrigerate.

Specimen Transport: Transport specimen to UWHC Core Laboratory (B4/220). Transport with coolant pack if coming from outreach location.

Unacceptable Criteria: Specimens collected in red cap with yellow ring (SST) tubes are not acceptable.

Stability: Ambient: 2 days
Refrigerated: 3 days
Frozen: 14 days


Interpretation

Interpretive Guidelines:

The relationship between therapeutic effect and free levels of carbamazepine has not been definitely established. Free carbamazepine levels have been reported to vary from 0.88 to 3.80 mcg/mL.

Critical Calls: View

Additional Information:

A result of "BELOW" indicates that the result is below the method detection limit of 0.5 mcg/mL.

 

This test was developed and its performance characteristics determined by the UWHC Clinical Laboratories.  This test meets the standards for clinical testing.  This test should not be regarded as investigational or for research use.  The US Food and Drug Administration (FDA) has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.

Free Tegretol Free Carbamazepine

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