UW Hospital and Clinics Lab Test Directory
| Test Name: |
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Alpha 2 Antiplasmin
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| Test Code(s): |
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A2AP / HCA2AP
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| CPT Code(s): |
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85410
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| Methodology: |
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Activity (Chromogenic)
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| Clinical Significance: |
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Test is used for the chromogenic determination of plasmin inhibitor (alpha 2-antiplasmin) activity in human plasma. Alpha 2-antiplasmin is the major fast-acting inhibitor of the fibrinolytic enzyme plasmin and an important regulator of the fibrinolytic system.
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| Request Form: |
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UWHC Special Coagulation Outreach Request Form (UWH SCLR-O)
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| Days Performed: |
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Mon-Fri, dayshift - day varies. Specimens are accepted at any time. Testing required during off hours must be approved by a Coagulation physician. Call 263-5005 before collection.
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| Turnaround Time: |
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Stat: 1 working day.
Routine: 4 - 7 working days.
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Specimen Requirements
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| Specimen: |
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Blood
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| Collection Instructions: |
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Do NOT draw through a line containing heparin. The venipuncture MUST be atraumatic to avoid hemolysis and contamination with tissue factors and platelets. Tube must be allowed to fill completely.
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| Collection Container: |
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Preferred: Light blue top (3.2% NaCitrate)
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| Collection Volume: |
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Preferred: Full 3.5 mL tube
Pediatrics: Pediatric tube filled to fill mark
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| Sample Analyzed: |
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Plasma
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| Volume Required: |
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Preferred: 1 mL
Pediatrics: 0.5 mL
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| Specimen Processing: |
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Centrifuge specimen to yield platelet poor plasma (platelet count should be less than 10 K/µL). Separate plasma and transfer to plastic tube or vial. Freeze plasma within 4 hours of collection at -20°C or below.
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| Specimen Transport: |
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Transport whole blood specimen at room temperature to UWHC Core Laboratory (B4/220) within 4 hours of collection. See Specimen Processing for instructions if transport criteria are not met. Transport frozen plasma aliquot on dry ice to UWHC Core Laboratory (B4/220).
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| Unacceptable Criteria: |
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Hemolyzed specimens, clotted specimens, partially filled tubes and whole blood specimens greater than 4 hours old when received by the laboratory are not acceptable.
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| Stability: |
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Ambient: 4 hours on a spun tube
Refrigerated: Not acceptable
Frozen: 2 weeks at -20°C; 6 month at -70°C
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Interpretation
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Reference Interval:
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| 0 days-29 days: |
60-130% |
| 30 days-5 months: |
75-140% |
| 6 months and up: |
85-150% |
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Plasmin inhibitor Antiplasmin
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