| Test Name: |
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Leukocytes, Fecal
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| Test Code(s): |
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FLEUK / FECWBC
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| CPT Code(s): |
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83630
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| Methodology: |
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Enzyme Immunoassay
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| Clinical Significance: |
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Detects the presence of leukocytes in stool: a positive test indicates inflammation which may be infectious or noninfectious, e.g. Crohns disease and ulcerative colitis.
"Routine examination of stool for fecal leukocytes is not recommended as a test for predicting bacterial infection or for selective testing for stool pathogens."
Guerrant R, et al. Practice guidelines for the management of infectious diarrhea. Clin Infec Dis 32:331-50, 2001
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| Days Performed: |
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Daily, 0700 - 2230.
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| Turnaround Time: |
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Stat: Not available stat.
Routine: 8 hours.
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Specimen Requirements
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| Specimen: |
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Stool
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| Collection Instructions: |
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Refrigerate specimen if transport is delayed.
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| Collection Container: |
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Preferred: Sterile screw cap container
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| Collection Volume: |
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Preferred: 1 mL
Pediatrics: 1 mL
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| Volume Required: |
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Preferred: 0.5 mL
Pediatrics: 0.5 mL
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| Specimen Transport: |
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Transport specimen to UWHC Microbiology Laboratory (B4/231) within 2 hours of collection; refrigerate if delay.
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| Unacceptable Criteria: |
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LIMIT: One specimen every 7 days.
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| Stability: |
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Ambient: 2 hours
Refrigerated: 48 hours
Frozen: Not acceptable
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Interpretation
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Expected Results:
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Negative
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| Test Limitations: |
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False negative test may occur in immunocompromised patients.
False positives may occur in breastfed infants.
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| Additional Information: |
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Infectious agents that cause inflammation include Shigella, Salmonella, Campylobacter, and enteroinvasive E. coli. Infectious agents that cause noninflammatory diarrhea include Vibrio species, enterotoxigenic E. coli, most parasites, all viral agents of gastoenteritis, and CMV. Clostridium difficile may or may not be accompanied by inflammation.
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