UW Hospital and Clinics Lab Test Directory
| Test Name: |
|
PR3 Ab
|
|
|
|
|
|
|
| Test Code(s): |
|
PR3 / HCPR3
|
|
|
|
|
|
|
| CPT Code(s): |
|
83520
|
|
|
|
|
|
|
| Methodology: |
|
Quantitative Enzyme Immunoassay
|
|
|
|
|
|
|
| Clinical Significance: |
|
Follow levels of this specific antibody in patients with Wegener's granulomatosis who have been shown to have PR3 antibodies (typically associated with C-ANCA pattern).
|
|
|
|
|
|
|
| Days Performed: |
|
Mon-Fri, dayshift - day varies.
|
|
|
|
|
|
|
| Turnaround Time: |
|
Stat: Not available stat.
Routine: 5 working days.
|
|
|
|
Specimen Requirements
|
|
|
|
| Specimen: |
|
Blood
|
|
|
|
|
|
|
| Collection Container: |
|
Preferred: Red top
Also Acceptable:
Red cap with yellow ring (SST)
|
|
|
|
|
|
|
| Collection Volume: |
|
Preferred: 3 mL
Pediatrics: 1 mL
|
|
|
|
|
|
|
| Sample Analyzed: |
|
Serum
|
|
|
|
|
|
|
| Volume Required: |
|
Preferred: 1 mL
Pediatrics: 0.3 mL
|
|
|
|
|
|
|
| Specimen Processing: |
|
Centrifuge. Transfer cell free serum to plastic vial. Refrigerate.
|
|
|
|
|
|
|
| Specimen Transport: |
|
Transport specimen to UWHC Core Laboratory (B4/220). Transport with coolant pack if coming from UWHC Satellite lab location.
|
|
|
|
|
|
|
| Outreach Specimen Transport: |
|
Transport specimen to UWHC Core Laboratory (B4/220). Transport with coolant pack if coming from outreach location.
|
|
|
|
|
|
|
| Unacceptable Criteria: |
|
Microbially contaminated, grossly hemolyzed, lipemic and turbid specimens are not acceptable.
|
|
|
|
|
|
|
| Stability: |
|
Ambient: 8 hours
Refrigerated: 7 days
Frozen: No limit at -20° C. Note: Avoid repeat freeze and thaw.
|
|
|
|
Interpretation
|
|
|
|
|
Reference Interval:
|
|
0 days and up: 0-20 Units
PR3 Ab Interpretive Guidelines:
|
0-20 Units
|
Negative |
|
21-30 Units
|
Weak Positive |
|
> 30 Units
|
Moderate to Strong Positive |
|
|
|
|
|
|
|
ANCA reflex
Protease 3 Antibodies
Anti-Serine Protease 3 Antibodies
Anti-Protease 3
|
