UW Hospital and Clinics Lab Test Directory
| Test Name: |
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Alpha-1-Antitrypsin
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| Test Code(s): |
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AAT / XA1A
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| CPT Code(s): |
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82103
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| Methodology: |
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Nephelometry
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| Clinical Significance: |
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Alpha-1-antitrypsin test aids in the diagnosis of alpha-1-antitrypsin deficiency associated with familial pulmonary emphysema and liver disease. Decreased serum alpha-1-antitrypsin may also be seen in prematurity, severe liver disease, malnutrition, renal protein loss and gastrointestinal protein loss. Serum alpha-1-antitrypsin may be increased in infection, neoplasia, pregnancy and use of birth control pills.
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| Days Performed: |
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Daily, 24 hours.
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| Turnaround Time: |
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Stat: 1 hour.
Routine: 4 days.
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Specimen Requirements
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| Specimen: |
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Blood
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| Collection Container: |
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Preferred: Green cap with yellow ring (PST)
Also Acceptable:
Green top,
Red cap with yellow ring (SST),
Red top
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| Collection Volume: |
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Preferred: 1 mL
Pediatrics: 0.4 mL
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| Sample Analyzed: |
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Plasma or serum
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| Volume Required: |
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Preferred: 0.5 mL
Pediatrics: 0.2 mL
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| Specimen Processing: |
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Centrifuge within 2 hours of draw. If a complete barrier has not formed, transfer cell-free plasma/serum to clear plastic vial. Refrigerate.
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| Specimen Transport: |
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Transport specimen to UWHC Core Laboratory (B4/220). Transport with coolant pack if coming from outreach location.
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| Stability: |
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Ambient: 8 hours
Refrigerated: 7 days
Frozen: 3 months
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Interpretation
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Reference Interval:
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0 days and up: 90-200 mg/dL
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