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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: Alpha-1-Antitrypsin

Test Code(s): AAT / XA1A

CPT Code(s): 82103

Methodology: Nephelometry

Clinical Significance: Alpha-1-antitrypsin test aids in the diagnosis of alpha-1-antitrypsin deficiency associated with familial pulmonary emphysema and liver disease. Decreased serum alpha-1-antitrypsin may also be seen in prematurity, severe liver disease, malnutrition, renal protein loss and gastrointestinal protein loss. Serum alpha-1-antitrypsin may be increased in infection, neoplasia, pregnancy and use of birth control pills.

Days Performed: Daily, 24 hours.

Turnaround Time: Stat: 1 hour.
Routine: 4 days.


Specimen Requirements

Specimen: Blood

Collection Container: Preferred: Green cap with yellow ring (PST)
Also Acceptable: Green top, Red cap with yellow ring (SST), Red top

Collection Volume: Preferred: 1 mL
Pediatrics: 0.4 mL

Sample Analyzed: Plasma or serum

Volume Required: Preferred: 0.5 mL
Pediatrics: 0.2 mL

Specimen Processing: Centrifuge within 2 hours of draw. If a complete barrier has not formed, transfer cell-free plasma/serum to clear plastic vial.  Refrigerate.

Specimen Transport: Transport specimen to UWHC Core Laboratory (B4/220). Transport with coolant pack if coming from outreach location.

Stability: Ambient: 8 hours
Refrigerated: 7 days
Frozen: 3 months


Interpretation

Reference Interval:

0 days and up: 90-200 mg/dL

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