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UW Health SMPH
American Family Children's Hospital

UW Hospital and Clinics Lab Test Directory

Test Name: C Reactive Protein, High Sensitivity

Test Code(s): HSCRP

CPT Code(s): 86141

Methodology: Nephelometry

Request Form: UWHC DOWNTIME Laboratory Request Form (UWH IPDOWNTIME, 4004202); Write in test if not on form.

Days Performed: Daily, 24 hours.

Turnaround Time: Stat: 1 hour.
Routine: 4 hours.


Specimen Requirements

Specimen: Blood

Collection Container: Preferred: Green cap with yellow ring (PST)
Also Acceptable: Green top, Red cap with yellow ring (SST), Red top

Collection Volume: Preferred: 4 mL
Pediatrics: 0.5 mL

Sample Analyzed: Plasma or serum

Volume Required: Preferred: 0.5 mL
Pediatrics: 0.2 mL

Specimen Processing: Centrifuge.  If a complete barrier has not formed, transfer cell-free plasma/serum to clear plastic vial.  Refrigerate.

Specimen Transport: Transport specimen to UWHC Core Laboratory (B4/220). Transport with coolant pack if coming from outreach location.

Stability: Ambient: 24 hours
Refrigerated: 7 days
Frozen: 8 months


Interpretation

When assessing risk of coronary heart disease, hs-CRP values should be used in conjunction with lipid values and other risk factors. Values in the 2nd and 3rd tertiles should be repeated and the average of the two values should be used for risk assessment. CRP is an acute phase reactant, so this test should not be obtained within 4 weeks of a systemic illness or myocardial infarction. Values greater than 5.0 mg/L may represent systemic inflammation.

 

Risk assessment: AHA/CDC Statement (Circulation 2003;107:499-511)

 

Tertile 1  < 1.0 mg/L   (low risk)  
Tertile 2  1.0-3.0 mg/L  (average risk)  
Tertile 3  > 3.0 mg/L  (high risk)  

Cardiac Risk High Sensitivity c-reacitve protein HS-CRP

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