Transplant and Coronary Heart Disease - Know Your Risks
The Risk
Heart disease is a leading cause of death in transplant patients. You can reduce your risk for heart disease by controlling your risk factors.
What is heart disease?
Coronary heart disease (CHD), also known as coronary artery disease (CAD) is a narrowing of the blood vessels that bring blood and oxygen to the heart. CHD puts patients at risk for having a heart attack or stroke.
Why am I at risk?
The medicines you take to prevent your body from rejecting the new organ can cause high blood pressure, increased blood sugar levels, and increased cholesterol. They can also affect how well your kidney(s) work. These side effects can be treated! If left untreated, they put you at a high risk for heart disease.
What are my risk factors?
There are things that increase your risk for heart disease. Some of these things you cannot change, but many you can. Talk with your transplant team about ways to reduce your risk!
Factors You Cannot Change
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Age |
Your risk increases, as you get older – being a male over 45 years or a female over 55 years old. |
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Personal history |
Have you had a heart attack, stroke, or coronary bypass? Having heart disease in the past increases your risk for having another heart attack or stroke. |
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Family history |
Having a parent or sibling who has had a stroke, heart attack, or known coronary artery disease (CAD) increases your risk. You are at greater risk if these occurred in a brother or father less than 55 yrs old or a sister or mother less than 65 yrs old. |
Factors You CAN Control!
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The Risk |
Goals |
Steps to achieve your goal |
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|---|---|---|---|
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Smoking |
Smokers have 2 to 4 times increased risk of coronary heart disease than nonsmokers.
Smoking raises your pulse and blood pressure, making the heart work harder. |
Maintain a smoke free lifestyle |
There are many options to help transplant patients stop smoking.
Buproprion (Wellbutrin/Zyban) or Varenicline (Chantix)
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High blood pressure |
High blood pressure is common after transplant. Certain anti-rejection medicines can cause your blood pressure to go up.
Having high blood pressure makes your heart work harder. |
Systolic (top number) 130 or less
Diastolic (bottom number) 80 or less.
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Ways to lower blood pressure
Some patients need to take medicine to keep blood pressures in the goal range. If you need medicines, be sure to take them on a regular basis.
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Abnormal cholesterol levels Total cholesterol Triglycerides (a form of fat) HDL (“Good” cholesterol) LDL: (“Bad” cholesterol) |
Anti-rejection drugs can cause high cholesterol levels. When a patient develops high cholesterol and/or triglyceride (fat) levels, blood vessels can become clogged, which affects the flow of blood. This slowing of blood flow can lead to a heart attack or stroke. As your total cholesterol rises, so does your risk of heart disesase. Having an HDL or “good” cholesterol less than 40 also significantly increases your risk. |
In general Total Cholesterol < 200 mg/dL
Triglycerides < 150 mg/dL
HDL ≥ 40 mg/dL
LDL < 100 mg/dL
Goals can vary from patient to patient based on risk factors. Talk to your healthcare team about your goals. |
Ways to improve your cholesterol
Some patients may need medicine to control cholesterol levels. Most of these medicines are safe for transplant patients, but be sure to discuss any new medicine with your transplant team. |
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Diabetes Increased blood sugar levels |
Certain anti-rejection medicines can make your blood sugar levels increase, leading to diabetes. Having diabetes greatly increases your risk of heart disease. Your risk is very high if you often have blood sugar levels that are not in the goal range.
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Patients with diabetes Aim for blood sugar levels of 70 to 140.
If you do not have diabetes fasting blood sugar levels should be 100 or less.
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Obesity |
More weight means more work for your heart. This can also lead to high blood pressure and diabetes. |
Talk with your healthcare team about your goal weight.
In general aim for a waist circumference of less than 35 inches for women and 40 inches for men.
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By losing even as few as 10 pounds, you can lower your heart disease risk.
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Not being active |
Lack of regular activity increases your risk for abnormal blood sugar levels, high blood pressure, and high cholesterol, all of which can increase your risk of heart disease. |
150 minutes of physical activity each week. |
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The information provided should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Any duplication or distribution of the information contained herein is strictly prohibited.
Last Updated: 09/19/2008
Copyright © 09/19/2008 University of Wisconsin Hospitals and Clinics Authority. All rights reserved. Produced by the Department of Nursing. HF#6779
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