Oral Targretin (Bexarotene)

Targretin is used for treatment of certain types of skin cancer (cutaneous T-cell lymphoma or CTCL).

 

Warning

Women who are pregnant, or who may become pregnant during treatment must not use this medicine.  Severe birth defects can occur.  Two forms of birth control must be used for 1 month before starting, and 1 month after treatment.

 

Dosage

Your doctor will prescribe the amount of medicine for you.

 

Side Effects

• Headache, rash, nausea, vomiting, dry skin, diarrhea, or trouble sleeping.
• Less common- yellowing eyes and skin, dark urine, vision changes, unusual weight loss.
• This medicine can make it harder for the body to fight an infection.
• Tell your doctor right away if you develop any signs of an infection, such as fever, chills, or a sore throat.

 

Precautions

Tell your doctor if you have a history of heart disease, high cholesterol or triglyceride levels, pancreatitis, diabetes, kidney, liver, or thyroid problems.  This medicine may make you more sun sensitive.  Wear sun screen or sunblock, and clothing to protect your skin.

 

Drug Interactions

Gemfibrozil, claithromycin, erythromycin, cimetidine, itraconazole, ketoconazole, nefazodone, phenytoin, phenobarbital, rifampin, vitamin A.  Do not eat grapefruit or drink grapefruit juice.

 

Missed Dose

If you miss a dose, take it as soon as you remember.  If it is near the time of the next dose, skip the missed dose and go back to your usual dosing schedule.  Do not take two doses to catch up.

 

Dermatology Clinic:  (608) 265-0700.

After hours, nights, holidays and weekends this number will give you the paging operator.  Ask for the Dermatology doctor on call.  Leave your name and phone number with the area code.  The doctor will call you back.

 

If you live outside the area, call 1-800-323-8942.

 

The information provided should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Any duplication or distribution of the information contained herein is strictly prohibited.

Last Updated: 06/13/2007

Copyright © 09/18/2006 University of Wisconsin Hospitals and Clinics Authority. All rights reserved. Produced by the Department of Nursing. UWH #6401

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