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Males who have Klinefelter syndrome may have an increased risk of:

• Learning disabilities.
• Skin conditions (eczema and ulcers of the leg).
• Diseases of blood vessels in the brain (cerebrovascular disease), such as stroke.
• Autoimmune diseases, such as diabetes, thyroiditis, lupus, Sjögren's syndrome, and rheumatoid arthritis.
• Chronic lung disease.
• Osteoporosis.
• Enlarged (varicose) veins.
• Breast cancer.