National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Neonatal Lupus is not the name you expected.
Neonatal lupus is a rare acquired autoimmune disorder that is present at birth (congenital). Affected infants often develop a characteristic red rash or skin eruption. The most significant potential complication is a heart condition known as congenital heart block. Congenital heart block does not resolve within the first several months of life and infants may ultimately require a pacemaker. Some infants develop only skin symptoms, some infants develop only heart symptoms, and, less often, some infants develop both. Less common findings include liver disease, an abnormally large head circumference (macrocephaly), and/or low numbers of circulating blood platelets that assist in blood clotting functions (thrombocytopenia), white blood cells that help fight infection (neutropenia), and red blood cells that help deliver oxygen to the body (anemia). Neonatal lupus results from specific autoantibodies that travel from a pregnant woman to her developing fetus. These autoantibodies damage specific fetal tissue through a process that is not fully understood.
Neonatal lupus is not the infant form of lupus (systemic lupus erythematosus); the name was given to this disorder because the skin rash resembles the one associated with lupus. The affected infant or child does not have systemic lupus erythematosus and often the mother does not either. Neonatal lupus is a distinct, separate disorder.
American Autoimmune & Related Diseases
- 22100 Gratiot Ave.
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Genetic and Rare Diseases (GARD) Information Center
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- Gaithersburg, MD 20898-8126
- Tel: (301)251-4925
- Fax: (301)251-4911
- Tel: (888)205-2311
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- Website: http://www.lupuscanada.org
Lupus Foundation of America, Inc.
- 2000 L Street NW
- Suite 710
- Washington, DC 20036
- Tel: (202)349-1155
- Fax: (202)349-1156
- Tel: (800)558-0121
- Email: firstname.lastname@example.org
- Website: http://www.lupus.org
March of Dimes
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NIH/National Institute of Child Health and Human Development
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- Tel: (800)370-2943
- Email: NICHDInformationResourceCenter@mail.nih.gov
- Website: http://www.nichd.nih.gov/
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
Last Updated: 10/28/2015
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