Dysplasia Epiphysealis Hemimelica

National Organization for Rare Disorders, Inc.

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It is possible that the main title of the report Dysplasia Epiphysealis Hemimelica is not the name you expected.

Disorder Subdivisions

  • None

General Discussion

Dysplasia epiphysealis hemimelica (DEH), also known as Trevor disease, is a raredevelopmental bone disorder of childhood. It is characterized by an abnormal overgrowth of cartilage arising from the cartilage which is normally present in the terminal ends (epiphyses) of the long bones particularly of the lower limbs. The bones of the knee and ankle joints are most commonly affected, as well as part of the foot (tarsal bones). The upper limbs are very rarely involved. The cartilage overgrowth occurs either in the medial or lateral part of the bone (hemimelic) usually medial. DEH may affect a single bone (localized form), multiple bones in a single limb (classical form) or an entire limb (generalized) usually involving a leg from the pelvis to the foot. Approximately two-thirds of affected children have multiple lesions.

DEH was first described in the medical literature in 1926. Trevor recognized this condition in 1950. The name, dysplasia epiphysealis hemimelica first appeared in the medical literature in 1956.

Supporting Organizations

American Academy of Orthopaedic Surgeons

6300 North River Road
Rosemont, IL 60018-4262
Tel: (847)823-7186
Fax: (847)823-8125
Email: custserv@aaos.org
Website: http://www.aaos.org/

Genetic and Rare Diseases (GARD) Information Center

PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
Website: http://rarediseases.info.nih.gov/GARD/

NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases

Information Clearinghouse
One AMS Circle
Bethesda, MD 20892-3675
Tel: (301)495-4484
Fax: (301)718-6366
Tel: (877)226-4267
Email: NIAMSinfo@mail.nih.gov
Website: http://www.niams.nih.gov/

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

Last Updated:  4/21/2016
Copyright  2016 National Organization for Rare Disorders, Inc.