National Organization for Rare Disorders, Inc.
It is possible that the main title of the report VACTERL Association is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
VACTERL association is a nonrandom association of birth defects that affects multiple median and para-median structures. The term VACTERL is an acronym with each letter representing the first letter of one of the more common findings seen in affected children:
(V) = (costo-) vertebral abnormalities
(A) = anal atresia
(C) = cardiac (heart) defects
(TE) = tracheal-esophageal abnormalities, including atresia, stenosis and fistula
(R) = renal (kidney) and radial abnormalities
(L) = (non-radial) limb abnormalities
(S) = single umbilical artery
Variability of such associations is wide and the relevance of each component usually varies by the observers. For this reason, from an original nucleus of "VATER" anomalies, the subsequent observation of an increased rate of heart malformations (C), non-radial limb anomalies (L) and single umbilical artery (S) expanded the phenotypic continuum grouping together all these conditions (i.e. VATER, VACTER, VACTERL and VACTERLS associations). At the moment, VACTERL association is the most frequently used term to define this condition. In addition, to the above mentioned features, affected children may also exhibit pre- and/or post-natal growth deficiency with failure to gain weight and grow at the expected rate (failure to thrive). Further low-frequency findings include facial asymmetry (hemifacial microsomia), external ear malformations, lung lobation defects, intestinal malrotation and genital anomalies. VATER/VACTERL features are more common in twinning. In some cases, the acronym VATER association is used. Mental functioning and intelligence is usually unaffected; developmental delay/mental retardation should suggest an alternative diagnosis. The exact cause of VACTERL association is unknown. Most cases occur randomly, for no apparent reason (sporadic).
March of Dimes Birth Defects Foundation
1275 Mamaroneck Avenue
White Plains, NY 10605
1705 Wintergreen Parkway
Normal, IL 61761
43 New Scotland Ave., MC-28
Albany Medical Center
Albany, NY 12208-3478
EA/TEF Child and Family Support Connection, Inc.
111 West Jackson Boulevard
Chicago, IL 60604-3502
Tracheo Oesophageal Fistula Support
St. George's Centre
91 Victory Road
Nottingham, NG4 2NN
VATER Connection Support
Birth Defect Research for Children, Inc.
976 Lake Baldwin Lane
Orlando, FL 32814
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Fetal Hope Foundation
9786 South Holland Street
Littleton, CO 80127
Cleft Lip and Palate Foundation of Smiles
2044 Michael Ave SW
Wyoming, MI 49509
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It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
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Last Updated: 3/16/2012
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