National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Sheehan syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
- postpartum hypopituitarism
- postpartum panhypopituitarism
- postpartum panhypopituitary syndrome
- postpartum pituitary necrosis
- Simmond's disease
Excessive blood loss during or after delivery of a baby may affect the function of the pituitary gland, leading to a form of maternal hypopituitarism known as Sheehan syndrome. Such extensive bleeding may reduce the blood flow to the pituitary gland and hence the amount of oxygen available to the cells of the brain and the gland. In such circumstances the pituitary cells may be damaged or die (necrosis) and thus the production of the usual pituitary hormones will be reduced, perhaps by a significant amount.
During pregnancy the pituitary gland will enlarge and may double in size. At this time the gland is especially vulnerable to "shock" and excessive maternal bleeding may induce the "shock" and the damage to the cells of the gland. At that time the balance of hormones produced by the pituitary may be thrown off giving rise to the symptoms associated with Sheehan syndrome.
There appear to be two forms of the disorder; a chronic form and an acute form, depending on the amount of damage to the gland's cells. The acute form reflects considerable damage so that symptoms become apparent soon after delivery. In chronic cases, the volume of damage is much less and symptoms may not appear for months or years after delivery.
NIH/National Institute of Diabetes, Digestive & Kidney Diseases
Office of Communications & Public Liaison
Bldg 31, Rm 9A06
31 Center Drive, MSC 2560
Bethesda, MD 20892-2560
Hormone Health Network Endocrine Society
2055 L Street NW
Washington, DC 20036
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
PO Box 1944
Bristol, BS99 2UB
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email email@example.com
Last Updated: 2/1/2012
Copyright 1986, 1989, 1998, 2002, 2007, 2009, 2012 National Organization for Rare Disorders, Inc.
Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.