Paget's Disease of the Breast
National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Paget's Disease of the Breast is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Synonyms Back to top
- Paget's Disease of the Nipple
- Mammary Paget's Disease
- Paget's Disease of the Nipple and Areola
Disorder Subdivisions Back to top
General Discussion Back to top
Paget's disease of the breast is a rare form of breast cancer that almost exclusively occurs in women. However, rare cases have been recorded in which men have been affected. The condition was originally reported in 1874 by Sir James Paget, an English surgeon, who also described an unrelated skeletal condition known as Paget's disease of the bone. It is essential to note that these disorders are distinct disease entities that are medically unrelated.
Paget's disease of the breast is characterized by inflammatory, "eczema-like" changes of the nipple that may extend to involve the areola, which is the circular, darkened (pigmented) region of skin surrounding the nipple. Initial findings often include itching (pruritus), scaling, and crusting of and/or discharge from the nipple. In those with Paget's disease of the breast, distinctive tumor cells (known as Paget cells) are present within the outermost layer of skin (epidermis) of the nipple. In addition, the condition is often associated with an underlying malignancy (i.e., cancer) of the milk ducts (ductal carcinoma). The malignancy may be confined to cells lining the milk ducts (carcinoma in situ) or may have invaded surrounding tissue (infiltrating carcinoma). (The milk ducts [lactiferous ducts] are the channels that carry milk secreted by lobes of the breast to the nipple.) Paget's disease of the breast is thought to represent approximately two to four percent of breast cancers.
Resources Back to top
National Women's Health Network
1413 K Street, NW
Washington, D.C. 20005
Skin Cancer Foundation
245 Fifth Avenue
New York, NY 10016
American Cancer Society, Inc.
1599 Clifton Road NE
Atlanta, GA 30329
Rose Kushner 's Women's Breast Cancer Advisory Center
P.O. Box 757
Malaga Cove, CA 90274
National Cancer Institute Physician Data Query
Office of Communications and Education
Public Inquiries Office
6116 Executive Blvd
Bethesda, MD 20892-8322
National Cancer Institute
6116 Executive Blvd
Bethesda, MD 20892-8322
Y-ME National Breast Cancer Organization
135 S LaSalle St
Chicago, IL 60607
OncoLink: The University of Pennsylvania Cancer Center Resource
3400 Spruce Street
Philadelphia, PA 19104-4283
SHARE - Self-Help For Women With Breast or Ovarian Cancer
New York, NY 10036
Canadian Breast Cancer Network
331 Cooper Street, Suite 300
Ontario, Intl K2P 0G5
Breast Cancer Society of Canada
420 East Street North
Ontario, N7T 6Y5
Rare Cancer Alliance
1649 North Pacana Way
Green Valley, AZ 85614
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Friends of Cancer Research
1800 M Street NW
Suite 1050 South
Washington, DC 22202
Cancer Support Community
1050 17th St NW
Washington, DC 20036
Lance Armstrong Foundation
2201 E. Sixth Street
Austin, TX 78702
For a Complete Report Back to top
This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email email@example.com
Last Updated: 4/1/2008
Copyright 1990, 2000 National Organization for Rare Disorders, Inc.
Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.