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Multiple System Atrophy

National Organization for Rare Disorders, Inc.

Important
It is possible that the main title of the report Multiple System Atrophy is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • MSA
  • progressive autonomic failure with multiple system atrophy
  • Shy-Drager syndrome (SDS)
  • sporadic olivopontocerebellar atrophy (sOPCA)
  • striatonigral degeneration (SND

Disorder Subdivisions

  • MSA-C (cerebellar phenotype)
  • MSA-P (parkinsonian phenotype)

General Discussion

Summary
Multiple system atrophy (MSA) is a rare sporadic progressive neurological disorder characterized by a varying combination of symptoms and signs. Onset is during adulthood (>30 years). Affected individuals may experience symptoms similar to those found in Parkinson's disease (parkinsonism); cerebellar signs such as progressive impairment of the ability to coordinate voluntary movements (cerebellar ataxia); and impaired functioning of the portion of the nervous system (autonomic nervous system) that regulates certain involuntary body functions (autonomic failure) such as heart rate, blood pressure, sweating, and bowel and bladder control. When parkinsonian symptoms predominate, the disorder may be referred to as MSA-P (parkinsonian phenotype); when the cerebellar symptoms predominate the disorder may be referred to as MSA-C (cerebellar phenotype). The exact cause of MSA is unknown.

Introduction
The term multiple system atrophy was first introduced in the medical literature in 1969. It encompasses three presentations of a single disease formerly thought to be separate disorders, specifically Shy-Drager syndrome (which emphasized autonomic dysfunction), striatonigral degeneration (which emphasized parkinsonian symptoms), and sporadic olivopontocerebellar atrophy (which emphasized cerebellar symptoms), although the cases of each of these that were originally described presented a combination of all three clinical features, and brain pathology was found in both the striatonigral and olivopontocerebellar structures. Additionally, there is a hereditary form of olivopontocerebellar atrophy that is not part of the multiple system atrophy spectrum.

Resources

WE MOVE (Worldwide Education and Awareness for Movement Disorders)
5731 Mosholu Avenue
Bronx, NY 10471
USA
Tel: (347)843-6132
Fax: (718)601-5112
Email: wemove@wemove.org
Internet: http://www.wemove.org

Parkinson's Disease Foundation, Inc.
1359 Broadway
Suite 1509
New York, NY 10018
Tel: (212)923-4700
Fax: (212)923-4778
Tel: (800)457-6676
Email: info@pdf.org
Internet: http://www.pdf.org

National Ataxia Foundation
2600 Fernbrook Lane Suite 119
Minneapolis, MN 55447
USA
Tel: (763)553-0020
Fax: (763)553-0167
Email: naf@ataxia.org
Internet: http://www.ataxia.org

CurePSP: Foundation for PSP l CBD & Related Brain Diseases
30 E. Padonia Road, Suite 201
Timonium, MD 21093
Tel: (410)785-7004
Fax: (410)785-7009
Tel: (800)457-4777
Email: info@curepsp.org
Internet: http://www.curepsp.org

NIH/National Institute of Neurological Disorders and Stroke
P.O. Box 5801
Bethesda, MD 20824
Tel: (301)496-5751
Fax: (301)402-2186
Tel: (800)352-9424
TDD: (301)468-5981
Internet: http://www.ninds.nih.gov/

Vanderbilt's Autonomic Dysfunction Center
Vanderbilt University Medical Center
1211 Medical Center Drive
Nashville, TN 37232-2195
USA
Tel: (615)322-5000
Fax: (615)343-8649
Email: david.robertson@vanderbilt.edu
Internet: http://www.mc.vanderbilt.edu/gcrc/adc

National Dysautonomia Research Foundation
PO Box 301
Red Wing, MN 55066-0102
Tel: (651)327-0367
Email: ndrf@ndrf.org
Internet: http://www.ndrf.org

Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
TDD: (888)205-3223
Internet: http://rarediseases.info.nih.gov/GARD/

SDS/MSA Support Group
8311 Brier Creek Parkway Suite 105-434
Raleigh, NC 27617
Tel: (866)737-4999
Email: Vjames@shy-drager.org or jbiedenharn@shy-drager.org
Internet: http://www.shy-drager.org

National Parkinson Foundation, Inc.
1501 NW 9th Ave/Bob Hope Road
Miami, FL 33136-1494
Tel: (305)243-6666
Fax: (305)243-6073
Tel: (800)327-4545
Email: contact@parkinson.org
Internet: http://www.parkinson.org

Movement Disorder Society
555 E. Wells Street
Suite 1100
Milwaukee, WI 53202-3823
Tel: (414)276-2145
Fax: (414)276-3349
Email: info@movementdisorders.org
Internet: http://www.movementdisorders.org

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  1/15/2013
Copyright  1986, 1987, 1988, 1991, 1992, 1994, 1998, 1999, 2000, 2003, 2013 National Organization for Rare Disorders, Inc.

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