Leiomyosarcoma

National Organization for Rare Disorders, Inc.

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Important
It is possible that the main title of the report Leiomyosarcoma is not the name you expected.

Disorder Subdivisions

  • None

General Discussion

Leiomyosarcoma is a malignant (cancerous) tumor that arises from smooth muscle Cells There are essentially two types of muscles in the body - voluntary and involuntary. Smooth muscles are involuntary muscles - the brain has no conscious control over them. Smooth muscles react involuntarily in response to various stimuli. For example, smooth muscle that lines the walls of the digestive tract causes wave-like contractions (peristalsis) that aid in the digestion and transport of food. Smooth muscles in the salivary glands cause the glands to squirt saliva into the mouth in response to taking a bite of food. Smooth muscle in the skin causes goose bumps to form in response to cold.

Leiomyosarcoma is a form of cancer. The term "cancer" refers to a group of diseases characterized by abnormal, uncontrolled cellular growth that invades surrounding tissues and may spread (metastasize) to distant body sites via the bloodstream, the lymphatic system, or other means. Different forms of cancer, including leiomyosarcomas, may be classified based upon the cell type involved, the specific nature of the malignancy, and the disease's clinical course. Leiomyosa usually spreads via the bloodstream. It is very rare to see it in lymphatics.

Since smooth muscle is found all over the body, a leiomyosarcoma can form almost anywhere where there are blood vessels, heart, liver, pancreas, genitourinary and gastrointestinal tract, the space behind the abdominal cavity (retroperitoneum), uterus, skin. The uterus is the most common location for a leiomyosarcoma. Most leiomyosarcomas of the gastrointestinal tract are now reclassified as gastrointestinal stromal tumors (GIST - see below)

Leiomyosarcoma is classified as a soft tissue sarcoma. Sarcomas are malignant tumors that arise from the connective tissue, which connects, supports and surrounds various structures and organs in the body. Soft tissue includes fat, muscle, nerves, tendons, and blood and lymph vessels. The exact cause of leiomyosarcoma, including uterine leiomyosarcoma, is unknown.

Supporting Organizations

American Cancer Society, Inc.

250 Williams NW St
Ste 6000
Atlanta, GA 30303
USA
Tel: (404)320-3333
Tel: (800)227-2345
Website: http://www.cancer.org

BeatSarcoma

76 Ellsworth Street
San Francisco, CA 94110
Tel: (415)826-0474
Email: info@beatsarcoma.org
Website: http://www.beatsarcoma.org/

Genetic and Rare Diseases (GARD) Information Center

PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
Website: http://rarediseases.info.nih.gov/GARD/

National Cancer Institute

6116 Executive Blvd Suite 300
Bethesda, MD 20892-8322
USA
Tel: (301)435-3848
Tel: (800)422-6237
Email: cancergovstaff@mail.nih.gov
Website: http://www.cancer.gov

Northwest Sarcoma Foundation

P.O. Box 91460
Portland, OR 97291
Tel: (503)954-5740
Email: jason@nwsarcoma.org
Website: http://www.nwsarcoma.org

OncoLink: The University of Pennsylvania Cancer Center Resource

3400 Spruce Street
2 Donner
Philadelphia, PA 19104-4283
USA
Tel: (215)349-8895
Fax: (215)349-5445
Email: hampshire@uphs.upenn.edu
Website: http://www.oncolink.upenn.edu

Rare Cancer Alliance

1649 North Pacana Way
Green Valley, AZ 85614
USA
Website: http://www.rare-cancer.org

Sarcoma Alliance

775 East Blithedale 334
Mill Valley, CA 94941
USA
Tel: (415)381-7236
Fax: (415)381-7235
Email: info@sarcomaalliance.org
Website: http://www.sarcomaalliance.org

Sarcoma Foundation of America

9899 Main Street Ste 204
Damascus, MD 20872
USA
Tel: (301)253-8687
Fax: (301)253-8690
Email: info@curesarcoma.org
Website: http://www.curesarcoma.org

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

Last Updated:  9/4/2012
Copyright  2012 National Organization for Rare Disorders, Inc.