Chromosome 9, Trisomy 9p (Multiple Variants)
National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Chromosome 9, Trisomy 9p (Multiple Variants) is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
- Trisomy 9P Syndrome (Partial), Included
- Chromosome 9, Partial Trisomy 9P, Included
- Chromosome 9, Complete Trisomy 9P
- Rethore Syndrome (obsolete)
- Duplication 9p Syndrome
- Dup(9p) Syndrome
- Chromosome 9, Trisomy 9pter-q11-13, Included
- Chromosome 9, Trisomy 9pter-q22-32, Included
This disease entry was made possible due to the generosity of the Robert Lee and Clara Guthrie Patterson Trust, through grant funds provided for the National Organization for Rare Disorders' "Pediatric Rare Disease Database Project."
Chromosome 9, Trisomy 9p is a rare chromosomal syndrome in which a portion of the 9th chromosome appears three times (trisomy) rather than twice in cells of the body. The trisomy may involve a portion of the short arm (9p), the entire short arm, or the short arm and a portion of the long arm (9q) of chromosome 9. (Each chromosome contains a short arm known as "p" and a long arm designated as "q.") Evidence suggests that, in many cases, associated symptoms and findings may be relatively similar among affected infants despite differing lengths of the trisomic (duplicated) segment of 9p. However, in those with larger trisomies (e.g., extending to middle or end [distal] regions of 9q), additional features may also be present that appear to correlate with the extent of the duplication.
Virtually all individuals with Trisomy 9p are affected by mental retardation and distinctive malformations of the skull and facial (craniofacial) region. In some instances, additional physical abnormalities may also be present, such as other skeletal defects, structural malformations of the heart that are present at birth (congenital heart defects), and/or other findings. In some cases, the trisomy appears to result from a balanced chromosomal rearrangement in one of the parents; in others, it is thought to arise from spontaneous (de novo) errors very early in embryonic development that occur for unknown reasons (sporadically).
Support Organization for Trisomy 18, 13, and Related Disorders
2982 S. Union Street
Rochester, NY 14624-1926
March of Dimes Birth Defects Foundation
1275 Mamaroneck Avenue
White Plains, NY 10605
1825 K Street NW, Suite 1200
Washington, DC 20006
PO Box 751112
Las Vegas, NV 89136
Trisomy 9 International Parent Support (9TIPS)
4027 E. Piedmont Drive
Highland, CA 92346
American Heart Association
7272 Greenville Avenue
Dallas, TX 75231
Support Organization for Trisomy 13/18 and Related Disorders, UK
c/o Christine Rose
48 Froggatts Ride
West Midlands, B76 2TQ SOFT
UNIQUE - Rare Chromosome Disorder Support Group
The Rare Chromosome Disorder Support Group
G1 The Stables
Station Road West, Oxted
Surrey, RH8 9EE
Email: firstname.lastname@example.org or email@example.com
Craniofacial Foundation of America
975 East Third Street
Chattanooga, TN 37403
Support Organisation for Trisomy and Related Disorders
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
For a Complete Report
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The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
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Last Updated: 4/7/2008
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