Neuroleptic Malignant Syndrome

National Organization for Rare Disorders, Inc.

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Important
It is possible that the main title of the report Neuroleptic Malignant Syndrome is not the name you expected.

Disorder Subdivisions

  • None

General Discussion

Neuroleptic malignant syndrome is a rare but potentially life-threatening reaction to the use of almost any of a group of antipsychotic drugs or major tranquilizers (neuroleptics). These drugs are commonly prescribed for the treatment of schizophrenia and other neurological, mental, or emotional disorders. Several of the more commonly prescribed neuroleptics include thioridazine, haloperidol, chlorpromazine, fluphenazine and perphenazine.

The syndrome is characterized by high fever, stiffness of the muscles, altered mental status (paranoid behavior), and autonomic dysfunction. Autonomic dysfunction alludes to defective operations of the components of the involuntary (autonomic) nervous system, leading to wide swings of blood pressure, excessive sweating and excessive secretion of saliva.

A genetic basis for the disorder is suspected but not proven. It does appear to be clear that a defect in the receptors to dopamine (dopamine D2 receptor antagonism) is an important contributor to the cause of neuroleptic malignant syndrome.

Supporting Organizations

Malignant Hyperthermia Association of the United States

1 North Main St
PO Box 1069
Sherburne, NY 13460
USA
Tel: (607)674-7901
Fax: (607)674-7910
Email: info@mhaus.org
Website: http://www.mhaus.org

MedicAlert Foundation International

2323 Colorado Avenue
Turlock, CA 95382
USA
Tel: (209)669-2401
Fax: (209)669-2456
Tel: (888)633-4298
Email: Inquiries@medicalert.org
Website: http://www.medicalert.org

Mental Health America

2000 N. Beauregard Street, 6th Floor
Alexandria, VA 22314-2971
USA
Tel: (703)684-7722
Fax: (703)684-5968
Tel: (800)969-6642
Email: infoctr@mentalhealthamerica.net
Website: http://www.mentalhealthamerica.net/

NIH/National Institute of Mental Health

Health Science Writing, Press and Dissemination Branch
6001 Executive Boulevard
Bethesda, MD 20892-9663
Tel: (301)443-4513
Fax: (301)443-4279
Tel: (866)615-6464
Email: nimhinfo@nih.gov
Website: http://www.nimh.nih.gov/index.shtml

National Alliance on Mental Illness

3803 N. Fairfax Drive
Suite 100
Arlington, VA 22203-
Tel: (703)524-7600
Fax: (703)524-9094
Tel: (800)999-6264
Email: membership@nami.org
Website: http://www.nami.org

National Mental Health Consumers' Self-Help Clearinghouse

1211 Chestnut Street
Suite 1207
Philadelphia, PA 19107-6312
USA
Tel: (215)751-1810
Fax: (215)636-6312
Tel: (800)553-4539
Email: info@mhselfhelp.org
Website: http://www.mhselfhelp.org

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

Last Updated:  5/1/2008
Copyright  2004 National Organization for Rare Disorders, Inc.