National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Corticobasal Degeneration is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Corticobasal degeneration (CBD) is a rare progressive neurological disorder characterized by cell loss and deterioration of specific areas of the brain. Affected individuals often initially experience motor abnormalities in one limb that eventually spreads to affect all the arms and legs. Such motor abnormalities include muscle rigidity and the inability to perform purposeful or voluntary movements (apraxia). Affected individuals may have sufficient muscle power for manual tasks, but often have difficulty directing their movements appropriately. Although CBD was historically described as a motor disease, it is now recognized that cognitive and behavioral symptoms also herald CBD and not uncommonly predate motor symptoms. Initial symptoms typically appear in people during the sixth decade, and may include poor coordination or difficulty accomplishing goal-directed tasks (e.g., buttoning a shirt). The exact cause of corticobasal degeneration is unknown.
Because signs and symptoms associated with corticobasal degeneration are frequently caused by other neurodegenerative disorders, researchers use the term "corticobasal syndrome" to indicate the clinical diagnosis based on signs and symptoms. The term "corticobasal degeneration" refers to those meeting the neuropathological criteria for the disorder at autopsy. This is an important distinction because clinicopathological series indicate that about less than half of patients diagnosed with corticobasal syndrome during life actually has corticobasal degeneration at autopsy.
CurePSP: Foundation for PSP l CBD & Related Brain Diseases
30 E. Padonia Road, Suite 201
Timonium, MD 21093
NIH/National Institute of Neurological Disorders and Stroke
P.O. Box 5801
Bethesda, MD 20824
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
UCSF Memory and Aging Center
350 Parnassus Avenue
San Francisco, CA 94117
Association for Frontotemporal Degeneration
Radnor Station Building #2, Suite 320
290 King of Prussia Road
Radnor, PA 19087
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It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
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Last Updated: 11/26/2012
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