Idiopathic Thrombocytopenic Purpura
National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Idiopathic Thrombocytopenic Purpura is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Idiopathic thrombocytopenic purpura (ITP) is a not infrequent autoimmune bleeding disorder characterized by the abnormally low levels of blood cells called platelets, creating a condition known as thrombocytopenia. Platelets are specialized blood cells that help prevent and stop bleeding by inducing clotting. In many ITP cases, there are no readily apparent causes or underlying disease (idiopathic), but frequently there are associated collagen vascular diseases or underlying neoplasms, most frequently lymphoid. The cells of the immune system, lymphocytes, produce anti-platelet antibodies that attach to the platelets. The presence of antibodies on platelets leads to their destruction in the spleen. The disorder is characterized by abnormal bleeding into the skin resulting in bruising, which is what the term purpura means. Bleeding from mucous membranes also occurs, and may subsequently result in low levels of circulating red blood cells (anemia).
ITP presents as a brief, self-limiting form of the disorder (acute ITP) or a longer-term form (chronic ITP). Acute ITP accounts for about 50% of cases, and chronic ITP accounts for the remainder. Eighty percent (80%) of the children with ITP have the acute form while the chronic form affects mostly adults. The acute form usually resolves without treatment (spontaneously) within three to six months. When thrombocytopenia lasts for more than six to 12 months, ITP is classified as the chronic form. Onset of acute ITP is often rapid, while the onset of the chronic form may be gradual.
American Autoimmune & Related Diseases
- 22100 Gratiot Ave.
- Eastpointe, MI 48021
- Tel: (586)776-3900
- Fax: (586)776-3903
- Tel: (800)598-4668
- Email: firstname.lastname@example.org
- Website: http://www.aarda.org/
- Website: https://www.facebook.com/autoimmunityforum
Autoimmune Information Network, Inc.
- PO Box 4121
- Brick, NJ 8723
- Fax: (732)543-7285
- Email: email@example.com
European Society for Immunodeficiencies
- 1-3 rue de Chantepoulet
- Geneva, CH 1211
- Tel: 410229080484
- Fax: 41229069140
- Email: firstname.lastname@example.org
- Website: http://www.esid.org
Genetic and Rare Diseases (GARD) Information Center
- PO Box 8126
- Gaithersburg, MD 20898-8126
- Tel: (301)251-4925
- Fax: (301)251-4911
- Tel: (888)205-2311
- Website: http://rarediseases.info.nih.gov/GARD/
- 30 Old Kings Hwy South Suite 275
- Darien, CT 6820
- Tel: (203)655-6954
- Fax: (203)548-9182
- Email: email@example.com
- Website: http://www.itpfoundation.org
ITP Support Association
- Kimbolton Road
- Bedfordshire, MK44 2EW
- United Kingdom
- Email: firstname.lastname@example.org
- Website: http://www.itpsupport.org.uk
NIH/National Heart, Lung and Blood Institute
- P.O. Box 30105
- Bethesda, MD 20892-0105
- Tel: (301)592-8573
- Fax: (301)251-1223
- Email: email@example.com
- Website: http://www.nhlbi.nih.gov/
NIH/National Heart, Lung and Blood Institute ~ Hematology Branch
- 10 Center Dr, Building 10-CRC
- 3-5140, MSC-1202
- Bethesda, MD 20892-1202
- Tel: (301)496-5093
- Fax: (301)496-8396
- Tel: (800)644-2337
- Email: YoungNS@mail.nih.gov
- Website: http://dir.nhlbi.nih.gov/labs/hb/index.asp
Platelet Disorder Support Association
- 133 Rollins Avenue, Suite 5
- Rockville, MD 20852
- Tel: (301)770-6636
- Fax: (301)770-6638
- Tel: (877)528-3538
- Email: firstname.lastname@example.org
- Website: http://www.pdsa.org
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email email@example.com
Last Updated: 1/6/1970
Copyright 2010 National Organization for Rare Disorders, Inc.
Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.