Mitral Valve Prolapse Syndrome
National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Mitral Valve Prolapse Syndrome is not the name you expected.
The mitral valve is the valve between the left upper and left lower chambers (left atrium and left ventricle) of the heart. Mitral valve prolapse syndrome (MVP) is a common condition in which one or both of the flaps (cusps) of the mitral valve bulge or collapse backward (prolapse) into the left atrium during ventricular contraction (systole). In some cases, this may allow leakage or the backward flow of blood from the left ventricle back into the left atrium (mitral regurgitation).
The exact underlying mechanism responsible for MVP remains unknown. In many affected individuals, the condition appears to occur in the absence of an associated disorder or syndrome (idiopathic). Evidence indicates that the condition is sometimes familial, suggesting autosomal dominant inheritance. In other cases, MVP occurs in association with certain inherited connective tissue diseases, other heart abnormalities, or other underlying conditions, disorders, or syndromes.
In many individuals with MVP, no associated symptoms are apparent (asymptomatic). However, in other cases, the condition may result in chest pain, abnormal heart rhythms (arrhythmias), fatigue, dizziness, and/or other symptoms and signs. MVP is often associated with a characteristic click and/or a subsequent delayed murmur that may be detected through use of a stethoscope during physical examination.
American Heart Association
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Genetic and Rare Diseases (GARD) Information Center
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March of Dimes
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NIH/National Heart, Lung and Blood Institute
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For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
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Last Updated: 5/16/2008
Copyright 2003 National Organization for Rare Disorders, Inc.
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