Amyotrophic Lateral Sclerosis
National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Amyotrophic Lateral Sclerosis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Synonyms Back to top
- Amyotrophic Lateral Sclerosis-Polyglucosan Bodies
- Aran-Duchenne Muscular Atrophy
- Gehrig's Disease
- Lou Gehrig's Disease
- Motor System Disease (Focal and Slow)
Disorder Subdivisions Back to top
- Spinal Muscular Atrophy, Type ALS
- Juvenile Spinal Muscular Atrophy, Included
- Progressive Bulbar Palsy, Included
- Benign Focal Amyotrophy of ALS
- Upper Motor Neuron Disease
- Werdnig-Hoffman Disease
- Primary Lateral Sclerosis
- Infantile Spinal Muscular Atrophy, ALS
- Kugelberg-Welander Disease
General Discussion Back to top
Amyotrophic lateral sclerosis (ALS) is one of a group of disorders known as motor neuron diseases. It is characterized by the progressive degeneration and eventual death of nerve cells (motor neurons) in the brain, brainstem and spinal cord that facilitate communication between the nervous system and voluntary muscles of the body. Ordinarily, motor neurons in the brain (upper motor neurons) sent messages to motor neurons in the spinal cord (lower motor neurons) and then to various muscles. ALS affects both the upper and lower motor neurons, so that the transmission of messages is interrupted, and muscles gradually weaken and waste away. As a result, the ability to initiate and control voluntary movement is lost. Ultimately, ALS leads to respiratory failure because affected individuals lose the ability to control muscles in the chest and diaphragm. ALS is often called Lou Gehrig's disease.
Resources Back to top
Amyotrophic Lateral Sclerosis Association
27001 Agoura Road
Calabasas Hills, CA 91301-5104
Families of Spinal Muscular Atrophy
925 Busse Road
Elk Grove Village, IL 60007
Muscular Dystrophy Association
3300 East Sunrise Drive
Tucson, AZ 85718-3208
NIH/National Institute of Neurological Disorders and Stroke
P.O. Box 5801
Bethesda, MD 20824
Les Turner Amyotrophic Lateral Sclerosis Foundation, Ltd.
5550 W. Touhy Avenue,
Skokie, IL 60077-3254
ALS Society of Ontario
3100 Steeles Ave E, Suite 402
Ontario, Intl L3R 8T3
Tel: (866) 611-8545
76 Firhill Rd
Glasgow, Intl G20 7BA
Tel: 0141 945 1077
Fax: 0141 945 2578
Spastic Paraplegia Foundation
7700 Leesburg Pike, Ste 123
Falls Church, VA 22043
International Alliance of ALS/MND Associations
P.O. Box 246
Northampton, NN1 2PR
Tel: 44 1604 611821
Fax: +44 1604 624 726
MUMS National Parent-to-Parent Network
150 Custer Court
Green Bay, WI 54301-1243
ALS Therapy Development Institute
215 First Street, 2nd Floor
Cambridge, MA 02142
Christopher Reeve Paralysis Foundation
636 Morris Turnpike, Suite 3A
Short Hills, NJ 07078
New Horizons Un-Limited, Inc.
811 East Wisconsin Ave
P.O. Box 510034
Milwaukee, WI 53203
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
UCSF Memory and Aging Center
350 Parnassus Avenue
San Francisco, CA 94117
For a Complete Report Back to top
This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email firstname.lastname@example.org
Last Updated: 9/29/2008
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