National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Machado-Joseph Disease is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
- Autosomal Dominant Spinocerebellar Degeneration
- Azorean Neurologic Disease
- Joseph Disease
- Machado Disease
- Nigrospinodentatal Degeneration
- Spinocerebellar Ataxia Type III (SCA 3)
- Striatonigral Degeneration, Autosomal Dominant Type
Machado-Joseph Disease (MJD-III), also called spinocerebellar ataxia type III, is a rare, inherited, ataxia (lack of muscular control) affecting the central nervous system and characterized by the slow degeneration of particular areas of the brain called the hindbrain. Patients with MJD may eventually become crippled and/or paralyzed but their intellect remains intact. The onset of symptoms of MJD varies from early teens to late adulthood.
Three forms of Machado-Joseph Disease are recognized: Types MJD-I, MJD-II, and MJD-III. The differences in the types of MJD relate to the age of onset and severity. Earlier onset usually produces more severe symptoms.
Genetic and Rare Diseases (GARD) Information Center
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International Joseph Disease Foundation, Inc.
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- Redding, CA 96099
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NIH/National Institute of Neurological Disorders and Stroke
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- Fax: (301)402-2186
- Tel: (800)352-9424
- Website: http://www.ninds.nih.gov/
National Ataxia Foundation
- 2600 Fernbrook Lane Suite 119
- Minneapolis, MN 55447
- Tel: (763)553-0020
- Fax: (763)553-0167
- Email: firstname.lastname@example.org
- Website: http://www.ataxia.org
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
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Last Updated: 1/23/1970
Copyright 2003 National Organization for Rare Disorders, Inc.
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